Cyclo-RGDyK-trifluoroacetate _Integrin 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECyclo(RGDyK) trifluoroacetateCat. No.: HY-100563CAS No.: 250612-42-1分式: CHFNO分量: 847.72Sequence: ArgGlyAspTyrLysSequence Shortening: RGDYK作靶点: Integrin作通路: Cytoskeleton储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-2

2、0C 1 month溶解性数据体外实验 DMSO : 130 mg/mL (153.35 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.1796 mL 5.8982 mL 11.7963 mL5 mM 0.2359 mL 1.1796 mL 2.3593 mL10 mM 0.1180 mL 0.5898 mL 1.1796 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选

3、择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (2.56 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD

4、 in saline)Solubility: 2.17 mg/mL (2.56 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (2.56 mM); Clear solution; Need warmingBIOLOGICAL ACTIVITY物活性 Cyclo(RGDyK) trifluoroacetate种有效的选择性 V3 整联蛋 (integrin) 抑制剂，IC50 为 20 nM。IC50 & Target IC50: 20 nM (V3 Integrin), 3000 nM

5、(IIb3 Integrin), 4000 nM (V5 Integrin) 1体外研究 Cyclo(RGDyK) (c(RGDyK(SAA) shows high affinity and selectivity for V3 over V5 (IC50=4000 nM) andIIb3 (IC50=3000 nM) 1.REFERENCES1. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics.J Nucl Med. 2001 Feb;42(2):326-36.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0