Loratadine-SCH-29851-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELoratadineCat. No.: HY-17043CAS No.: 79794-75-5Synonyms: SCH 29851; Loratidine分式: CHClNO分量: 382.88作靶点: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling储存式: Powder -20C 3 years4C 2 yearsIn solvent

2、 -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (130.59 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6118 mL 13.0589 mL 26.1178 mL5 mM 0.5224 mL 2.6118 mL 5.2236 mL10 mM 0.2612 mL 1.3059 mL 2.6118 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案

3、，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.53 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.53 mM); Clear solutio

4、n1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.53 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Loratadine(SCH-29851)是H1受体反向激动剂，IC5032 M。REFERENCES1. Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cogni

5、tion, psychomotor performance, mood andsedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50.2. Menardo JL, Horak F, Danzig MR, Czarlewski W. A review of loratadine in the treatment of patients with allergic bronchial asthma. ClinTher. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4.3. Monroe EW. Lor

6、atadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19(2):232-42.4. Haria M, Fitton A, Peters DH. Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders.Drugs. 1994 Oct;48(4):617-37.5. Roman IJ, Danzig MR. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at itsuse in combination with pseudoephedrine. Clin Rev Allergy. 1993 Spring;11(1):89-110.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only