Ciprofloxacin-hydrochloride-Bay-09867-hydrochloride-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECiprofloxacin hydrochlorideCat. No.: HY-B0356ACAS No.: 93107-08-5Synonyms: Bay-09867 (hydrochloride)分式: CHClFNO分量: 367.8作靶点: Bacterial作通路: Anti-infection储存式: 4C, protect from light, stored under nitrogen* 该产品在溶液状态不稳定，建议您现现配，即刻使。

2、溶解性数据体外实验 H2O : 12.5 mg/mL (33.99 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7189 mL 13.5943 mL 27.1887 mL5 mM 0.5438 mL 2.7189 mL 5.4377 mL10 mM 0.2719 mL 1.3594 mL 2.7189 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现现配，即刻使。BIOLOGICAL ACTIVITY物活性 Ciproflo

3、xacin hydrochloride (Bay-09867 (hydrochloride)种氟喹诺酮类抗素，具有效的抗菌活性。IC50 & Target Bacterial 1体外研究 Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride) is a fluoroquinolone antibiotic, exhibiting potentantibacterial activity 1. Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride) (CIP) shows potent a

4、ctivityagainst Y. pestis with MIC90 of 0.03 g/mL 2.1/3 Master of Small Molecules 您边的抑制剂师www.MedChemE体内研究 Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride) (1 mg/L) induces glutathione-S-transferase (GST)activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxaci

5、n. Ciprofloxacinhydrochloride (10 g/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes inanuran amphibian larvae 1. In a murine model of pneumonic plague, Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride) (30 mg/kg, i.p.) results in a drug exposure which is simila

6、r to the drug exposureobserved in human following a 500 mg dose of oral Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride).Intraperitoneal Ciprofloxacin hydrochloride reduces the lung bacterial load compare to controls treated withintraperitoneal PBS 3.PROTOCOLCell Assay 2 Bacterial inocula are

7、prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containingCiprofloxacin hydrochloride) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar(SBA) plates that are incubated at 35C. Suspended cultures are diluted with CAMHB to a bacterial celldensity of 105 CF

8、U/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50L of dilutions is added for a final inoculum of 5104 CFU/well. Plates are incubated at 35C. MICs aredetermined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm2.

9、MCE has not independently confirmed the accuracy of these methods. They are for reference only.Animal Female BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (4 g) are used in this assay. A singleAdministration 3 dose of Ciprofloxacin hydrochloride (30 mg/kg) is administered to mice (n=30) via

10、 the intraperitoneal (i.p.)route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h followingCiprofloxacin hydrochloride (Bay-09867 (hydrochloride) administration and 1, 15, or 30 min and 1, 2, 4, 6,10, 18, or 24 h following DRCFI or CFI administration. Blo

11、od sampling points are chosen based upon theshort half-life of Ciprofloxacin hydrochloride and longer half-life of CFI. Blood and lungs (whole organ) arecollected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculatedusing the concentration of Ciprofloxacin hyd

12、rochloride (Bay-09867 (hydrochloride) in the lung samples at 1min post-administration 3.MCE has not independently confirmed the accuracy of these methods. They are for reference only.户使本产品发表的科研献 Chemosphere. 2019 Mar. Int J Antimicrob Agents. 2018 Aug;52(2):269-271.See more customer validations on H

13、YPERLINK / www.MedChemEREFERENCES1. Peltzer PM, et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ ToxicolPharmacol. 2017 Feb 4. pii: S1382-6689(17)30029-7.2/3 Master of Small Molecules 您边的抑制剂师www.MedChemE2. Steenbergen J, et al. In Vitro

14、and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersiniapestis. Antimicrob Agents Chemother. 2017 Feb 21.3. Hamblin KA, et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. FrontMicrobiol. 2017 Fe