Niraparib-metabolite-M1-Niraparib-carboxylic-acid-metabolite-M1-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENiraparib metabolite M1Cat. No.: HY-G0023CAS No.: 1476777-06-6Synonyms: Niraparib carboxylic acid metabolite M1; M1 metabolite ofniraparib分式: CHNO分量: 321.37作靶点: Drug Metabolite作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 yea

2、rs4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (311.17 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1117 mL 15.5584 mL 31.1168 mL5 mM 0.6223 mL 3.1117 mL 6.2234 mL10 mM 0.3112 mL 1.5558 mL 3.1117 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂

3、配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (8.56 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline

4、)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.75 mg/mL (8.56 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (8.56 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Niraparib metabolite M1niraparib 的代谢物。Niraparib 种新颖的 PARP 抑制剂。体外研究 Niraparib metabolite M1 has t

5、he validation in plasma and urine for the support of clinical studies such as themass balance study and the absolute bioavailability study 1.REFERENCES1. van Andel L, et al. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 inhuman plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 19;1040:14-21McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;