RIPK1-IN-7 - RIPK1 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERIPK1-IN-7Cat. No.: HY-119933CAS No.: 2300982-44-7分式: CHFNO分量: 481.47作靶点: RIP kinase作通路: Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (129.81 mM; Need ultrasonic)H2O

2、: 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.32 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.32 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 RIPK1-IN-7受体相互作蛋激酶 1 (RIPK1) 抑制剂，Kd 值为 4 nM，IC50 值为 11 nM。RIPK

3、1-IN-7 在 实验性 B16 素瘤肺转移模型中具有良好的抗转移活性 1。IC50 & Target IC50: 11 nM (RIPK1) 1Kd: 4 nM (RIPK1) 1体外研究 RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC50of 2nM 1.RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, Tr

4、kA, TrkB, TrkC, Axl,HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively 1.REFERENCES1. Li Y, et al. Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo2,3- dpyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. J Med Chem. 2018 Dec27;61(24):11398-11414.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;