Fexaramine - FXR Agonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFexaramineCat. No.: HY-10912CAS No.: 574013-66-4分式: CHNO分量: 496.64作靶点: FXR作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (100.68 mM; Need ultrasonic)

2、Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0135 mL 10.0677 mL 20.1353 mL5 mM 0.4027 mL 2.0135 mL 4.0271 mL10 mM 0.2014 mL 1.0068 mL 2.0135 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂

3、前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.03 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.03 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 FexaramineFXR受体分激动剂。

4、户使本产品发表的科研献 Int J Mol Med. 2018 Sep;42(3):1723-1731.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J PhysiolGastrointest Liver Physiol. 2009 Jul;297(1

5、):G90-7.2. Cho SW, et al. Positive regulation of osteogenesis by bile acid through FXR. J Bone Miner Res. 2013 Oct;28(10):2109-21.3. Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015Feb;21(2):159-65.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-