CAY10471-Racemate-TM30089-Racemate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECAY10471 RacemateCat. No.: HY-13706CAS No.: 844639-57-2Synonyms: TM30089 Racemate分式: CHFNOS分量: 416.47作靶点: Prostaglandin Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 D

2、MSO : 150 mg/mL (360.17 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4011 mL 12.0057 mL 24.0113 mL5 mM 0.4802 mL 2.4011 mL 4.8023 mL10 mM 0.2401 mL 1.2006 mL 2.4011 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，

3、体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.00 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.00 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil

4、1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.00 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 CAY10471 Racemate (TM30089 Racemate)种有效、度选择性的前列腺素 D2 受体 (CRTH2) 拮抗剂，对hCRTH2 的 Ki 值为 0.6 nM，对其选择性远于栓素 A2 受体 TP (Ki，10000 nM) 或 PGD2 受体 DP(Ki，1200 nM)。CAY10471 Racemate 对和的同 CRTH2 也具有

5、拮抗作 1。IC50 & Target Ki: 0.6 nM (CRTH2), 1200 nM (DP) 1体外研究 CAY10471 Racemate (Compound 13) inhibits PGD2-induced inositol phosphate or cAMP formation,suppresses -arrestin translocation with IC50s of 12 and 3 nM, respectively 1.REFERENCES1. Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potentCRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379