SKF-86002 - p38 MAPK 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESKF-86002Cat. No.: HY-12511CAS No.: 72873-74-6分式: CHFNS分量: 297.35作靶点: p38 MAPK作通路: MAPK/ERK Pathway储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 33.33 mg/mL (112.09 mM; Need ultrasonic)Ma

2、ss Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3630 mL 16.8152 mL 33.6304 mL5 mM 0.6726 mL 3.3630 mL 6.7261 mL10 mM 0.3363 mL 1.6815 mL 3.3630 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的

3、百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.41 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.41 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 SKF-86002是p38MAPK抑制剂，IC50值为0.

4、5-1uM。REFERENCES1. Griswold DE, et al. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediatedmetabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.2. Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and

5、 -independent intracellular signal transduction pathways leading toapoptosis in human neutrophils. J Biol Chem. 1998 Apr 3;273(14):8389-97.3. Nick JA, et al. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.J Clin Invest. 1997 Mar 1;99(5):975-86.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02