EMT-inhibitor-1 - Hippo (MST) 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEMT inhibitor-1Cat. No.: HY-101275CAS No.: 1638526-21-2分式: CHClNOS分量: 319.21作靶点: Hippo (MST); TGF-beta/Smad; Wnt作通路: Stem Cell/Wnt; TGF-beta/Smad储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMS

2、O : 100 mg/mL (313.27 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1327 mL 15.6637 mL 31.3273 mL5 mM 0.6265 mL 3.1327 mL 6.2655 mL10 mM 0.3133 mL 1.5664 mL 3.1327 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，

3、再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.83 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.83 mM); Clear solution3. 请依序添加每种溶剂：

4、10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (7.83 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 EMT inhibitor-1是Hippo，TGF- 和 Wnt 信号通路的抑制剂，并拥有抗肿瘤活性。IC50 & Target Hippo, TGF-, Wnt 1.体外研究 EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-, and Wnt signal

5、ing pathways with antitumor activities,inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro 1.体内研究 EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMTinhibitor-1 induces GSK3-mediated degradation of the Hippo transduc

6、er TAZ, through activation of theHippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex 1.REFERENCES1. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-, and Wnt signalingpathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: