Tat-NR2B9c-TFA-NA-1-TFA-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETat-NR2B9c TFACat. No.: HY-P0117ACAS No.: 1834571-04-8Synonyms: NA-1 (TFA)分式: CHFO分量: 114.02Sequence: Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-ValSequence Shortening:YGRKKRRQRRRKLSSIESDV作靶点: iG

2、luR; NO Synthase作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;Immunology/Inflammation储存式: -20C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 H2O : 50 mg/mL (438.52 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concen

3、tration制备储备液1 mM 8.7704 mL 43.8520 mL 87.7039 mL5 mM 1.7541 mL 8.7704 mL 17.5408 mL10 mM 0.8770 mL 4.3852 mL 8.7704 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性Tat-NR2B9c TFA (NA-1 TFA)由 20 个氨酸组成的多肽，为 PSD-95 的抑制剂，对 PSD-95d2 和 PSD-95d1的 EC50 值分别为 6.7 nM 和 670 nM 1。Tat-NR2B9c 同

4、时可降低 NMDA 诱导的 p38 的活化，抑制神经元型1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE氧化氮合酶/PSD-95 (nNOS/PSD-95) 的相互作，具有神经保护作 1 2。IC50 & Target EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1) 1NO synthase 1户使本产品发表的科研献 J Cereb Blood Flow Metab. 2018 Mar 7:271678X18762637. Sci Rep. 2018 May 18;8(1):7848.See more cu

5、stomer validations on HYPERLINK / www.MedChemEREFERENCES1. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. JNeurosci. 2007 Sep 12;27(37):9901-15.2. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntingtondisease. Neurobiol Dis. 2012 Mar;45(3):999-1009.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792