TH588-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETH588Cat. No.: HY-12814CAS No.: 1609960-31-7分式: CHClN分量: 295.17作靶点: DNA/RNA Synthesis作通路: Cell Cycle/DNA Damage储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 16 mg/mL (54.21 mM; Need ultra

2、sonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3879 mL 16.9394 mL 33.8788 mL5 mM 0.6776 mL 3.3879 mL 6.7758 mL10 mM 0.3388 mL 1.6939 mL 3.3879 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液

3、可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.47 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.47 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.

4、47 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 TH588MTH1 (NUDT1) 效选择性抑制剂，IC50 值 5 nM 1。IC50 & Target IC50: 5 nM (MTH1) 1体外研究 TH588 (2-10M; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, andSW620 cells with IC50s of 1.

5、38, 0.83, 1.03, 1.08, 1.72, 0.8 M 1.Cell Viability Assay 1Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cellsConcentration: 2, 4, 6, 8, 10 MIncubation Time: 7-10 daysResult: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, andSW620 cells with IC50s of 1.3

6、8, 0.83, 1.03, 1.08, 1.72, 0.8 M, but was less toxic toseveral primary or immortalized cells.体内研究 TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model 1.Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model) 1Dosage: 30 mg/kgAdministra

7、tion: Subcutaneous injection; once daily for 35 daysResult: Reduced tumour growth in SW480 xenograft cancer model.户使本产品发表的科研献 J Mol Med (Berl). 2019 Jun 14.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.McePdfHeightCaution: Product has not been fully validated for medical applications.For researc