AZD8329 - 11β-HSD1 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAZD8329Cat. No.: HY-18173CAS No.: 1048668-70-7分式: CHNO分量: 421.53作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (148.27 mM; Need ultrasonic)Mass Solvent1 mg

2、 5 mg 10 mg Concentration制备储备液1 mM 2.3723 mL 11.8616 mL 23.7231 mL5 mM 0.4745 mL 2.3723 mL 4.7446 mL10 mM 0.2372 mL 1.1862 mL 2.3723 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液

3、中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.93 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (4.93 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.93 mM); Clear solution1/2 Maste

4、r of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 AZD8329种有效的 11-羟甾类脱氢酶 1 型 (11-HSD1) 抑制剂，对11-HSD1 的IC50 值为 9 nM，与11-HSD2、17-HSD1、17-HSD3 相，表现出良好的选择性 1。IC50 & Target IC50: 9 nM (Human 11-HSD1) 1体外研究 AZD8329 shows IC50s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 M for human enzyme, ra

5、t enzyme,dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively 1.REFERENCES1. Scott JS, et al. Novel acidic 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitor with reduced acyl glucuronide liability: thediscovery of 4-4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-ylbenzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;