UCB9608 - PI4K 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEUCB9608Cat. No.: HY-112613CAS No.: 1616413-96-7分式: CHNO分量: 410.47作靶点: PI4K作通路: PI3K/Akt/mTOR储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 65 mg/mL (158.36 mM; Need ultrasonic)Mass Solvent

2、1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4362 mL 12.1812 mL 24.3623 mL5 mM 0.4872 mL 2.4362 mL 4.8725 mL10 mM 0.2436 mL 1.2181 mL 2.4362 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配

3、制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.07 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.07 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.07 mM); Clear solution1/2 M

4、aster of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 UCB9608种有效、选择性、可服的 PI4KIII 抑制剂，IC50 值为 11 nM，对其选择性于 PI3KC2， 和 。UCB9608 增加了代谢稳定性，表现出良好的药代动学特征，可作为免疫抑制剂 1。体外研究 UCB9608 is a potent, selective and orally active PI4KIII inhibitor, with an IC50 of 11 nM. UCB9608 isselective for PI4KIII o

5、ver PI3KC2 , , and lipid kinases 1.UCB9608 inhibits human mixed lymphocyte reaction, the IC50 is 37 nM 1.REFERENCES1. Reuberson J, et al. Discovery of a Potent, Orally Bioavailable PI4KIII Inhibitor (UCB9608) Able To Significantly Prolong AllogeneicOrgan Engraftment in Vivo. J Med Chem. 2018 Aug 9;61(15):6705-6723.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02