Alendronic-acid-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAlendronic acidCat. No.: HY-B0631CAS No.: 66376-36-1分式: CHNOP分量: 249.1作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 8.33 mg/mL (33.44 mM; Need ultrasonic)Mass Solvent

2、1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.0145 mL 20.0723 mL 40.1445 mL5 mM 0.8029 mL 4.0145 mL 8.0289 mL10 mM 0.4014 mL 2.0072 mL 4.0145 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Alendronic acid，种双膦酸盐，法呢磷酸合酶 (FDPS) 抑制剂。Alendronic acid 抑制破细胞介导的吸收。Alendronic acid 对绝经后质疏松症，恶性

3、钙症和 Paget 病具有疗效。体外研究 Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates,alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects onbone remodeling, a process that is critically important for fracture healing

4、 2.REFERENCES1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE1. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293.2. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone MinerRes. 2019 Jun;34(6):1025-1032.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa