Mito-apocynin-C2-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEMito-apocynin(C2)Cat.No.:HY-135868CASNo.:1254044-41-1分⼦式:C₂₈H₂₇BrNO₃P分⼦量:536.4作⽤靶点:MitochondrialMetabolism作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性数据体外实验DMSO:100mg/mL(186.43mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.8643mL9.3214mL18.6428mL5mM0.3729mL1.8643mL3.7286mL10mM0.1864mL0.9321mL1.8643mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(4.66mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(4.66mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(4.66mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性Mito-apocynin(C2)，⼀种于三苯膦(TPP)为靶点的⼝服活性线粒体化合物。Mito-apocynin(C2)由Apocynin部分与TPP+阳离⼦结合⽽合成。Mito-apocynin(C2)具有抗炎作⽤。体内研究Mito-apocynin(C2)(3mg/kg;p.o.;dailyfor12days)exhibitsantineuroinflammatoryeffect[1].AnimalModel:MPTPmicemodelofParkinson’sDisease[1]Dosage:3mg/kgAdministration:Oralgavage;dailyfor12daysResult:SignificantlyattenuatedMPTP-inducedglialcellactivation,proinflammatorycytokineupregulation,induciblenitricoxidesynthase,andNOX2components(gp91phox).REFERENCES[1].ZielonkaJ,etal.Mitochondria-TargetedTriphenylphosphonium-BasedCompounds:Syntheses,MechanismsofAction,andTherapeuticandDiagnosticApplications.ChemRev.2017Aug9;117(15):10043-10120.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-