Carindacillin-sodium-Carbenicillin-indanyl-sodium-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECarindacillinsodiumCat.No.:HY-108880CASNo.:26605-69-6Synonyms:Carbenicillinindanylsodium;CP-15464-2分⼦式:C₂₆H₂₅N₂NaO₆S分⼦量:516.54作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:250mg/mL(483.99mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.9360mL9.6798mL19.3596mL5mM0.3872mL1.9360mL3.8719mL10mM0.1936mL0.9680mL1.9360mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.03mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(4.03mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.03mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Carindacillin(Carbenicillinindanyl)sodium⼀种具有⼝服活性的⼴谱抗剂。Carindacillinsodium在体内可⽔解为Carindacillin。Carindacillinsodium可⽤于尿路感染的研究。体外研究Carindacillinsodiumisactiveagainstabroadspectrumofbacterialspeciesinvitro[1].体内研究Carindacillinsodium(p.o.)protectsmiceagainstlethalinfectionsproducedbyEscherichiacoli,Salmonellacholeraesuis,Pasteurellamultocida,Proteusvulgaris,Staphylococcusaureus,andStreptococcuspyogenes,withPD95srangingfrom30.4mg/kgto220.4mg/kg[1].REFERENCES[1].EnglishAR,et,al.Carbenicillinindanylsodium,anorallyactivederivativeofcarbenicillin.AntimicrobAgentsChemother.1972Mar;1(3):185-91.[2].RiesKM,et,al.Comparisonofcarbenicillinindanylsodium,ampicillin,andcephaloglycinintreatmentofurinary-tractinfection.JInfectDis.1973May;127:Suppl:148-53.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon