Metronidazole-hydrochloride-SC-326421-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMetronidazolehydrochlorideCat.No.:HY-B0318ACASNo.:69198-10-3Synonyms:SC326421分⼦式:C₆H₁₀ClN₃O₃分⼦量:207.61作⽤靶点:Antibiotic;Bacterial;Parasite;Apoptosis作⽤通路:Anti-infection;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Metronidazolehydrochloride(SC326421)⼀种具有⼝服活性的硝咪唑类抗⽣素，能⽤于研究厌氧微⽣物的感染。Metronidazolehydrochloride能够穿过⾎脑屏障，长期使⽤会导致炎症和⾻骼肌收缩。体外研究Metronidazolehydrochlorideactsonanaerobicmicroorganismfollowing:passagethroughthecellmembrane;(b)reductiveaction;(c)interactionwithintracellulartargets;(d)releaseofinactiveendproducts,exertsfunctionwithtoxicnitroandnitrosoderivatives[1].MetronidazolehydrochloridedisplaysinhibitoryactivitytowardsanaerobicprotozoaTrichomonasvaginalis,Entamoebahistolytica,Giardialamblia,andBalantidiumcoli[1].Metronidazolehydrochloride(4-8μg/mL)inhibitsanaerobicbacteriaandshowsgoodbactericidalactivity[1].Metronidazolehydrochloride(0.1μg/mL-0.01mg/mL;12-96h)inducesgranularformationandtriggersapoptosisinBlastocystissp[2].ApoptosisAnalysis[2]CellLine:Blastocystissp.CellsConcentration:0.1μg/mL-0.01mg/mLIncubationTime:12,24,48,60,72,84,96hoursResult:Decreasedcelldiameter,asahallmarkofanapoptoticcell,andresultedcellshrinkage.体内研究Metronidazolehydrochloride(135mg/kg/d;p.o.;28d)cancrossthebloodbrainbarrier,andexhibits1/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEneurotoxicityunderlongtermadministrationinrats[3].Metronidazolehydrochloride(1g/L;p.o.;4weeks)resultsskeletalmuscleatrophyandchangestheexpressionofgenesinvolvedinthemuscleperipheralcircadianrhythmmachineryandmetabolicregulation[4].AnimalModel:Sprague-Dawley(SD)rats(200-220g)[3]Dosage:135mg/kgAdministration:Oralgavage;oncedaily;28daysResult:Causedinflammatorymarkersincreasing,includingiNOS,eNOS,Baxandcaspase3proteinexpressionsincreasingandcausedoxidativestressdamageinbraintissue,withMDAcontentrising.AnimalModel:SPFC57Bl/6Jmice(6-7monthsold)[4]Dosage:1g/L(fulldose)Administration:Oralgavage;providedwithdrinkingwaterfor4weeks,changedtwiceweeklyResult:ResultedthemusclecoreclockandeffectorgenesCry2,Ror-β,E4BP4,PPARγandadiponectinexpressionincreasing.Decreasedhindlimbmuscleweightandresultedinsmallerfibersinthetibialisanteriormuscle.户使⽤本产品发表的科研⽂献•EmergMicrobesInfect.2022Feb22;1-34.•Microbiome.2020Aug20;8(1):120.•CellRep.2020Dec1;33(9):108438.•CellDeathDis.2021Jun7;12(6):582.•LifeSci.2020Nov15;261:118473.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ScullyBE.Metronidazole.MedClinNorthAm.1988May;72(3):613-21.[2].DhurgaDB,etal.GranularFormationduringApoptosisinBlastocystissp.ExposedtoMetronidazole(MTZ).PLoSOne.2016Jul29;11(7):e0155390.[3].ChaturvediS,etal.Mechanisticexplorationofquercetinagainstmetronidazoleinducedneurotoxicityinrats:Possibleroleofnitricoxideisoformsandinflammatorycytokines.Neurotoxicology.2020Jul;79:1-10.[4].ManickamR,etal.MetronidazoleCausesSkeletalMuscleAtrophyandModulatesMuscleChronometabolism.IntJMolSci.2018Aug2/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE16;19(8):2418.McePdfHeightCaution:Producthasnot