DiMNF-3-4-Dimethoxy-αNF-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDiMNFCat.No.:HY-103222CASNo.:14756-24-2Synonyms:3',4'-Dimethoxy-αNF分⼦式:C₂₁H₁₆O₄分⼦量:332.35作⽤靶点:ArylHydrocarbonReceptor作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:12.5mg/mL(37.61mM;ultrasonicandwarmingandheatto70°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.0089mL15.0444mL30.0888mL5mM0.6018mL3.0089mL6.0178mL10mM0.3009mL1.5044mL3.0089mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性DiMNF(3',4'-Dimethoxy-αNF)⼀种选择性芳烃受体(AHR)调节剂。DiMNF⼀种具有明显拮抗活性的竞争性AHR配体(IC50=21nM)。DiMNF可⽤作抗炎剂。体外研究DiMNF(3',4'-Dimethoxy-αNF)(10μM;4h)minimallyinfluencesAHRgenebattery[1].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEDiMNF(10μM;1h)effectivelysuppressescytokine-mediatedinflammatorygeneexpression[1].DiMNFadoptsauniqueorientationwithintheligandbindingpocketofAHR[1].RT-PCR[1]CellLine:Huh7cellConcentration:10μMIncubationTime:4hor1hResult:DecreasedCYP1A1mRNAexpression(4h).Exhibitedrepressiveactivitytowardcytokine-mediatedSAA1induction(1h).SignificantlyreducedIL1β-mediatedmRNAinductionofC4,C1S,C1R,andC3.REFERENCES[1].MurrayIA,etal.Suppressionofcytokine-mediatedcomplementfactorgeneexpressionthroughselectiveactivationoftheAhreceptorwith3',4'-dimethoxy-α-naphthoflavone.MolPharmacol.2011Mar;79(3):508-19.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5