脑胶质瘤诊疗规范(2018年版)

诊断主要依靠计算机断层扫描CT）磁共振成像MRI） 磁共振弥散加权成像DWI） （co-deletion）O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子区甲基化、1/45 2/45 3/454/45 5/45氨基酸PET和 6/45 7/45

免疫组织化学胶质纤维酸性蛋白GFAP）波形蛋白Vimentin）Ki-67/MIB-1、蛋白、 8/45（2）GBM①GBM，IDH野生型9/45免疫组织化学GFAP、p53蛋白、S-100、Vimentin、10/4511/45免疫组织化学GFAP、NCAM1、S-100、OLIG2、MAP2、p53蛋白、ATRX、H3K27M。裊樣祕廬廂颤谚12/4513/45免疫组织化学GFAP、S-100、14/4515/45见或缺如，Ki-67/MIB-1增殖指数<5%；III级表现为细胞密度增高，核异型性明显，核分裂像增多， 16/4517/45活检35-38，目前具体标准尚不统一。劇妆诨貰攖苹埘呂仑庙。18/45 《国际抗癫痫联盟ILAE） 19/4520/4521/45 22/45的CTV1中（46Gy/23f）23/45 24/4525/45口服TMZ150-200mg/m2/d，连用5天，每28天重复，共用6个周期107，137。

②PCV方案：甲基苄肼（PCB）60mg/m2/dd8-21，洛莫司汀（CCNU）110mg/m2/dd1，长春新碱（VCR）1.4mg/m2d8，d29，8周为一周期109。弃铀縫迁馀氣鰷鸾觐廩。 26/45莫司汀/洛莫司汀161，TMZ，卡铂162，163）⑥伊利替康164，165；⑦环磷酰胺166，167；⑧以卡27/4528/45 29/4530/4531/45 组**

究**

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