Golgicide-A-GCA-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGolgicideACat.No.:HY-100540CASNo.:1139889-93-2Synonyms:GCA分⼦式:C₁₇H₁₄F₂N₂分⼦量:284.3作⽤靶点:Enterovirus作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(351.74mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.5174mL17.5871mL35.1741mL5mM0.7035mL3.5174mL7.0348mL10mM0.3517mL1.7587mL3.5174mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(8.79mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(8.79mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性GolgicideA(GCA)⼀种有效的，⾼度特异性的，可逆的式⾼尔体ADP-核糖化因⼦鸟嘌呤核苷酸交换因⼦(ArfGEFGBF1)抑制剂。GolgicideA可抑制柯萨奇病毒B3(CVB3)和其他⼈类肠道病毒的复制。IC50&TargetGBF1[1]体外研究GolgicideA(GCA)isapotentandhighlyeffectiveinhibitorofshigatoxinactivity.GolgicideA(GCA)inhibitstheeffectofshigatoxinonproteinsynthesiswithanIC50of3.3μM[1].户使⽤本产品发表的科研⽂献•MolMetab.2021Dec;54:101329.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SáenzJB,etal.GolgicideArevealsessentialrolesforGBF1inGolgiassemblyandfunction.NatChemBiol.2009Mar;5(3):157-65.[2].vanderLindenL,etal.DifferentialeffectsoftheputativeGBF1inhibitorsGolgicideAandAG1478onenterovirusreplication.JVirol.2010Aug;84(15):7535-42.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3