Mycro-3-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMycro3Cat.No.:HY-100669CASNo.:944547-46-0分⼦式:C₂₄H₁₇ClF₂N₆O₄分⼦量:526.88作⽤靶点:c-Myc;Autophagy作⽤通路:Apoptosis;Autophagy储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥100mg/mL(189.80mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM1.8980mL9.4898mL18.9797mL5mM0.3796mL1.8980mL3.7959mL10mM0.1898mL0.9490mL1.8980mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoil1/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:2.5mg/mL(4.74mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性Mycro3⼀种具有⼝服活性的、有效的选择性Myc-Max⼆聚化抑制剂[1]。Mycro3可⽤于胰腺癌的研究。IC50&TargetMyc-MAXdimerization[1]体外研究Mycro3isapotentandselectivec-Mycinhibitorinwholecellassays,withweakinhibitoryactivityagainstActivatorprotein1(AP-1).Mycro3hasasuperiorspecificityprofiletoitspredecessors.Mycro3inhibitstheinteractionbetweenc-MycandMax.Mycro3hashighselectivityandinhibitsc-Myc/MaxdimerizationandconjugationwithDNA[1].Mycro3exhibitsanexcellentspecificitywithIC50sof0.25and9.0µMforcellswithintactMycallelesandMyc-nullcells,respectively[2].体内研究Mycro3(100mg/kg;oraladministration;dailyfortwomonths)inducesmarkedshrinkageofpancreaticductaladenocarcinoma(PDA),increasescancercellapoptosis,andreducescellproliferation.TumorgrowthisalsodrasticallyattenuatedinMycro3-treatedNOD/SCIDmicecarryingorthotopicorheterotopicxenograftsofhumanpancreaticcancercells[2].AnimalModel:MoribundPdx1-cre/KRAS*micebearingpancreaticductaladenocarcinoma(PDA)[2]Dosage:100mg/kgAdministration:Oraladministration;dailyfortwomonthsResult:Increasedsurvivaltime.Mycro3administrationwasdiscontinuedaftertwomonths,themousesurvivedforanadditionalmonth.户使⽤本产品发表的科研⽂献•CellMolImmunol.2022Sep;19(9):1030-1041.•CellDeathDis.2020Sep15;11(9):760.•CancerCellInt.2021Dec14;21(1):670.•ResearchSquarePreprint.2021Sep.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ChenBJ,etal.Smallmoleculestargetingc-Myconcogene:promisinganti-cancertherapeutics.IntJBiolSci.2014Sep13;10(10):1084-96.[2].DimitrisStellas,etal.Therapeuticeffectsofananti-Mycdrugonmousepancreaticcancer.JNatlCancerInst.2014Oct2/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE11;106(12):dju320.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedic