NKL-22-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENKL22Cat.No.:HY-100384CASNo.:537034-15-4分⼦式:C₁₉H₂₃N₃O₂分⼦量:325.4作⽤靶点:HDAC作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(307.31mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.0731mL15.3657mL30.7314mL5mM0.6146mL3.0731mL6.1463mL10mM0.3073mL1.5366mL3.0731mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性NKL22(化合物4b)⼀种有效的选择性组蛋⽩脱⼄酰酶(HDAC)抑制剂，抑制HDAC1和HDAC3的IC50值分别为199和69nM。NKL22对HDAC2/4/5/7/8(IC50≥1.59μM)具有选择性。NKL22改了亨廷顿⽒病转因⼩⿏的疾病表型和转录异常。IC50&TargetHDAC1HDAC2HDAC3HDAC81/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE0.199μM(IC50)1.59μM(IC50)0.069μM(IC50)5μM(IC50)户使⽤本产品发表的科研⽂献•JMolMed(Berl).2019Aug;97(8):1183-1193.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].DHermanetal.HistonedeacetylaseinhibitorsreversegenesilencinginFriedreich'sataxia.NatChemBiol,2006Oct,2(10):551-8.[2].JiaH,et,al.Histonedeacetylase(HDAC)inhibitorstargetingHDAC3andHDAC1amelioratepolyglutamine-elicitedphenotypesinmodelsystemsofHuntington'sdisease.NeurobiolDis.2012May;46(2):351-61.[3].ThomasEA,et,al.TheHDACinhibitor4bamelioratesthediseasephenotypeandtranscriptionalabnormalitiesinHuntington'sdiseasetransgenicmice.ProcNatlAcadSciUSA.2008Oct7;105(40):15564-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5