SG3199-Val-Ala-PAB-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESG3199-Val-Ala-PABCat.No.:HY-101152CASNo.:1595275-61-8分⼦式:C₄₉H₅₉N₇O₁₁分⼦量:922.03作⽤靶点:Drug-LinkerConjugatesforADC作⽤通路:Antibody-drugConjugate/ADCRelated储存⽅式:-20°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性数据体外实验DMSO:130mg/mL(140.99mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.0846mL5.4228mL10.8456mL5mM0.2169mL1.0846mL2.1691mL10mM0.1085mL0.5423mL1.0846mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥3.25mg/mL(3.52mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥3.25mg/mL(3.52mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性SG3199-Val-Ala-PABTesirine合成的中间体。Tesirine⼀种⽤于抗体偶联药物(ADC)的药物-linker连接物，能⽤于多种癌症的研究。体外研究SG3199-Val-Ala-PABisanintermediateininthesynthesisofTesirine,anantibody-drugconjugatepyrrolobenzodiazepinedimerpayload[1].REFERENCES[1].TiberghienAC,et,al.DesignandSynthesisofTesirine,aClinicalAntibody-DrugConjugatePyrrolobenzodiazepineDimerPayload.ACSMedChemLett.2016May24;7(11):983-987.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021