SR0987-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESR0987Cat.No.:HY-101454CASNo.:303126-97-8分⼦式:C₁₆H₁₀ClF₆NO₂分⼦量:397.7作⽤靶点:ROR作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥150mg/mL(377.17mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5145mL12.5723mL25.1446mL5mM0.5029mL2.5145mL5.0289mL10mM0.2514mL1.2572mL2.5145mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(6.29mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.29mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.29mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性SR0987SR1078的⼀个类似物，RORγt的⼀个激动剂，其EC50值为800nM。SR0987可上调IL17的表达且抑制PD-1的表达。IC50&TargetEC50:800nM(RORγt)[1].体外研究SR0987clearlyshowsaconcentrationdependentinductionofreportergeneexpressionwithanEC50of~800nM.SR0987treatmentresultsinastatisticallysignificantreductionofthesurfaceexpressionofPD-1whereasdesmostroltreatmentshowsnoeffect.TreatmentwithSR0987andordesmosterolresultsinatrendtowardsincreasedIL17production[1].户使⽤本产品发表的科研⽂献•SciAdv.2021Jan22;7(4):eabe4827.•WorldJEmergMed.2022;13(1):32-37.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ChangMR,etal.SyntheticRORγtAgonistsEnhanceProtectiveImmunity.ACSChemBiol.2016Apr15;11(4):1012-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:40