IACS-8803-disodium-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEIACS-8803disodiumCat.No.:HY-130115ACASNo.:2243079-36-7分⼦式:C₂₀H₂₃FN₁₀Na₂O₉P₂S₂分⼦量:738.51作⽤靶点:STING作⽤通路:Immunology/Inflammation储存⽅式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性数据体外实验H2O:56.67mg/mL(76.74mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.3541mL6.7704mL13.5408mL5mM0.2708mL1.3541mL2.7082mL10mM0.1354mL0.6770mL1.3541mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：PBSSolubility:50mg/mL(67.70mM);Clearsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性IACS-8803disodium⼀种⾼效环状⼆核苷酸的STING激动剂，具有强⼤的全⾝抗肿瘤作⽤。体内研究IACS-8803(10µg;intra-tumoralinjection)showssuperiorantitumoractivityinmicebearingbilateralB16-OVAmelanomas[1].REFERENCES[1].AgerCR,etal.DiscoveryofIACS-8803andIACS-8779,potentagonistsofstimulatorofinterferongenes(STING)withrobustsystemicantitumorefficacy.BioorgMedChemLett.2019Oct15;29(20):126640.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a