Cefilavancin-TD-1792-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECefilavancinCat.No.:HY-19466CASNo.:1393900-12-3Synonyms:TD-1792分⼦式:C₈₇H₉₅Cl₃N₁₆O₂₈S₂分⼦量:1983.26作⽤靶点:Bacterial;Antibiotic作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Cefilavancin(TD-1792)⼀种有效的多价糖肽-头孢类异⼆聚体抗⽣素(antibiotic)，有效抵抗⾰兰⽒阳性(bacteria)。Cefilavancin已被⽤于研究⽪肤感染。IC50&TargetGlycopeptide体外研究Cefilavancin(TD-1792)hashighlyactiveagainstMethicillin-susceptibleStaphylococcusaureus(MIC90=15ng/mL),Methicillin-resistantStaphylococcusaureus,andheterogeneousVancomycin-intermediateStaphylococcusaureus(MIC90=30ng/mL)[1].体内研究Cefilavancin(0.03-10mg/kg;s.c.)producesadose-dependentreductionofthighbacterialburdenininfectedmice[3].AnimalModel:FemaleNSAmice(18-30g;neutropeniainducedbyadministeringcyclophosphamide,theninjectedbacteriaintotheposteriorthigh)[3]Dosage:0.03-10mg/kgAdministration:s.c.;singledosage(every24h)ortwo(every12h),three(every8h),orfour(every6h)divideddosesResult:Producedamaximalofapproximately1-to2-log10killagainstMRSAATCC33591,MSSAATCC29213,andMRSEMED820and≥3-log10killagainstVISAHIP5836,1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEMSSESU03,PSSPMED35,PSSPMED1119,andStreptococcuspyogenesMED2040strains.REFERENCES[1].BlaisJ,etal.AntistaphylococcalactivityofTD-1792,amultivalentglycopeptide-cephalosporinantibiotic.AntimicrobAgentsChemother.2012Mar;56(3):1584-7.[2].StryjewskiME,etal.TD-1792versusvancomycinfortreatmentofcomplicatedskinandskinstructureinfections.AntimicrobAgentsChemother.2012Nov;56(11):5476-83.[3].HegdeSS,etal.PharmacodynamicsofTD-1792,anovelglycopeptide-cephalosporinheterodimerantibioticusedagainstGram-positivebacteria,inaneutropenicmurinethighmodel.AntimicrobAgentsChemother.2012Mar;56(3):1578-83.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: