Canthaxanthin-E-161g-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECanthaxanthinCat.No.:HY-B1960CASNo.:514-78-3Synonyms:E161g;all-trans-Canthaxanthin分⼦式:C₄₀H₅₂O₂分⼦量:564.84作⽤靶点:ReactiveOxygenSpecies;EndogenousMetabolite作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB储存⽅式:-20°C,protectfromlight,storedundernitrogen*该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤。溶解性数据体外实验DMSO:1mg/mL(1.77mM;ultrasonicandwarmingandheatto80°C)H2O:1mg/mL(1.77mM;ultrasonicandwarmingandheatto80°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7704mL8.8521mL17.7041mL5mM---------10mM---------请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤.BIOLOGICALACTIVITY⽣物活性Canthaxanthin具有多种⽣物活性的红橙⾊类胡萝⼘素，如抗氧化，抗肿瘤活性。IC50&TargetHumanEndogenousMetabolite体外研究CanthaxanthinenrichmentofLDLhasthepotentialtoprotectcholesterolfromoxidation.Inadditiontoitsfreeradicalscavengingandantioxidantproperties(e.g.,theinductionofcatalaseandsuperoxidedismutase),1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEcanthaxanthinshowsimmunomodulatoryactivity(e.g.enhancingtheproliferationandfunctionofimmunecompetentcells)andplaysimportantroleingapjunctioncommunication(e.g.inductionofthetransmembraneproteinconnexin)[1].Atconcentrationsof0.1to1x1000μM,canthaxanthinsignificantlyreducestheoverallnumberoftumorcells.Thegreatestinhibitionisobservedatacanthaxanthinconcentrationof1000after72hand96hofincubation[2].体内研究Canthaxanthinalterstheprotectiveabilityoftissuesagainstoxidativestress.Canthaxanthintreatmentfor15datthedoseof14μg/kgbodyweightresultsinhepaticincorporationofthecarotenoid,whichismaximuminliverandreaches0.52±0.05nmol/gliver.Glutathioneperoxidaseactivityis35%lowerandcatalase(59%)andmanganesesuperoxidedismutase(28%)activitiesarehigherincanthaxanthin-treatedmicethanincontrols[3].Canthaxanthininhibitthegrowthofmammarytumorsinmiceandtheanti-tumoractivityisalsoinfluencedbythesupplementaldose[4].Dietsupplementationwithcanthaxanthinfor3weekspriortothecarcinogenresultsina65%reductioninthenumberofmammarycancersbyamechanismnotinvolvingpro-vitaminAactivity[5].PROTOCOLAnimalMice:Female6-wk-oldBalb/cmicearerandomlydividedintotwogroups(n=10/group).ThecontrolgroupAdministration[3]receivesoliveoilalone(vehicle)andthecanthaxanthin-treatedgroupreceivescanthaxanthinatadoseof14μg/kgbodyweightperday.Attheendofthetreatment,micearekilledbycervicaldislocationandliverisexcised,frozeninliquidnitrogenandstoredat−80°C[3].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.户使⽤本产品发表的科研⽂献•FASEBJ.2020Oct;34(10):13430-13444.•BiochemBiophysResCommun.2018Sep3;503(1):297-303.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].EsatbeyogluT,etal.Canthaxanthin:Frommoleculetofunction.MolNutrFoodRes.2017Jun;61(6).[2].HuangDS,etal.Inhibitoryeffectsofcanthaxanthinoninvitrogrowthofmurinetumorcells.CancerLett.1992Aug31;65(3):209-13.[3].PalozzaP,etal.CanthaxanthinsupplementationaltersantioxidantenzymesandironconcentrationinliverofBalb/cmice.JNutr.2000May;130(5):1303-8.[4].ChewBP,etal.Acomparisonoftheanticanceractivitiesofdietarybeta-carotene,canthaxanthinandastaxanthininmiceinvivo.AnticancerRes.1999May-Jun;19(3A):1849-53.[5].GrubbsCJ,etal.Effectofcanthaxanthinonchemicallyinducedmammarycarcinogenesis.Oncology.1991;48(3):239-45.McePdfHeightCaution:Produ