Salidroside-Standard-Rhodioloside-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemESalidroside(Standard)Cat.No.:HY-N0109RCASNo.:10338-51-9Synonyms:Rhodioloside(Standard)分子式:C₁₄H₂₀O₇分子量:300.31作用靶点:ProlylEndopeptidase(PREP);mTOR;Apoptosis作用通路:MetabolicEnzyme/Protease;PI3K/Akt/mTOR;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验H2O:≥100mg/mL(332.99mM)DMSO:100mg/mL(332.99mM;Needultrasonic)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM3.3299mL16.6495mL33.2989mL5mM0.6660mL3.3299mL6.6598mL10mM0.3330mL1.6649mL3.3299mLBIOLOGICALACTIVITY生物活性Salidroside(Standard)是Salidroside的分析标准品。本产品用于研究及分析应用。Salidroside(Rhodioloside)是一种脯氨酰内肽酶(prolylendopeptidase)抑制剂。Salidroside可通过激活mTOR信号缓解肿瘤恶病质小鼠模型中的恶病质症状。Salidroside还能通过增强PINK1/Parkin介导的线粒体自噬来保护多巴胺能神经元。IC50&TargetProlylendopeptidase[1]mTOR[2]1/3 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemE体外研究Salidroside(100μM)inhibitsprolylendopeptidase(PEP)activity(10.6±1.9%).Prolylendopeptidaseisanenzymethatplaysaroleinthemetabolismofproline-containingneuropeptidasewhichisrecognizedtobeinvolvedinlearningandmemory[1].Salidroside,oneofthemajorphenylpropanoidglycosidesfoundinR.?roseaL,isconsumedalmostdailyasanutritionalsupplementinmanycountriesandhasbeenidentifiedpossessingpotentialanti-fatigueandanoxia,anti-aging,andanti-Alzheimer'sdiseaseactivities.SalidrosidecanimprovemusclenutritionviaincreasingmTOR,p-mTOR,andMyHCexpression[2].SH-SY5Ycellsareexposedto0-600?μMMPP+for12-48?handtheresultsshowthatMPP+resultsinasignificantdecreaseofcellviabilityinaconcentrationandtime-dependentmanner.Cellsarepretreatedwith25-100?μMSalidroside(Sal)for24?handthenexposedto500?μMMPP+foranadditional24?h.Salidrosideconcentration-dependentlypreventsMPP+-induceddecreaseofcellviability.AnnexinV/PIstainingisacommonmethodforthedetectionofapoptoticcell.SalidrosidesignificantlydecreasesthenumberofAnnexinV/PI-stainedcellstreatedbyMPP+whichisinaconcentration-dependentmanner.ApoptoticcellcouldalsobemorphologicallyevaluatedbyHoechststaining.InHoechststaining,apoptoticcellsarecharacterizedbyreducednuclearsize,chromatincondensation,intensefluorescence,andnuclearfragmentation.SalidrosidenotablyinhibitsMPP+-inducedincreaseofchromatincondensation,intensefluorescence,andnuclearfragmentationinSH-SY5Ycells[3].体内研究SalidrosideisanaturalantioxidantextractedfrommedicinalfoodplantRhodiolarosea.Salidroside(100mg/kg/day)showsstrongglucoseloweringeffectondb/dbmicewhichissimilartoeffectofMetformin(200mg/kg/day)[4].Salidrosidecanbeusedtoinducetesticularinjurymodelinmice[6].客户使用本产品发表的科研文献ChemEngJ.1May2022,135115.Phytomedicine.2022Jan29;99:153964.FreeRadicBiolMed.2024Feb2:214:54-68.IntImmunopharmacol.2023Mar20;117:109975.FrontPharmacol.2020Nov11;11:580407.Seemorecustomervalidationsonwww.MedChemEREFERENCESWangZ,etal.SalidrosideAmelioratesFuran-InducedTesticularInflammationinRelationtotheGut-TestisAxisandIntestinalApoptosis.JAgricFoodChem.2023Nov9.LiR,etal.SalidrosideProtectsDopaminergicNeuronsbyEnhancingPINK1/Parkin-MediatedMitophagy.OxidMedCellLongev.2019Sep10;2019:9341018.FanW,etal.ProlylendopeptidaseinhibitorsfromtheundergroundpartofRhodiolasachalinensis.ChemPharmBull(Tokyo).2001Apr;49(4):396-401.JuL,etal.Salidroside,ANaturalAntioxidant,Improvesβ-CellSurvivalandFunctionviaActivatingAMPKPathway.FrontPharmacol.2017Oct18;8:749.2/3 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEChenX,etal.SalidrosidealleviatescachexiasymptomsinmousemodelsofcancercachexiaviaactivatingmTORsignalling.JCachexiaSarcopeniaMuscle.2016May;7(2):225-32.WuL,etal.SalidrosideProtectsagainstMPP+-InducedNeuronalInjurythroughDJ-1-Nrf2AntioxidantPathway.EvidBasedComplementAlternatMed.2017;2017:5398542.Mce