Linalool-13C3-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemELinalool-13C3Cat.No.:HY-N0368S1分子式:C₇₁₃C₃H₁₈O分子量:157.23作用靶点:Apoptosis;EndogenousMetabolite;iGluR;Bacterial;Isotope-LabeledCompounds作用通路:Apoptosis;MetabolicEnzyme/Protease;MembraneTransporter/IonChannel;NeuronalSignaling;Anti-infection;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Linalool-13C3是13C标记的α-Hexylcinnamaldehyde(HY-W014118)。α-Hexylcinnamaldehyde，一种衍生自肉桂醛的化合物。α-Hexylcinnamaldehyde具有潜在的抗诱变和化学增敏特性。α-Hexylcinnamaldehyde被广泛用作许多个人护理品的成分，以及食品和制药行业的添加剂。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].Linalool(0-2000μM,24-72h)caninduceapoptosisofcancercells(U87-MG,HepG-2,SW620andsoon)throughoxidativestresswhileprotectingnormalcellsPC12[4].Linalool(0-2000mg/mL,0-72h)exertsantibacterialeffectsbydamagingcellmembranes[4].Linalool(0-2mM,24-48h)inhibitsA549cellproliferationbyinducingG0/G1and/orG2/Mcellcyclearrest,andwithoutaffectingthecellviabilityofnormallungWI-38cells.LinaloolinhibitsA549cellmigration[5].体内研究Linalool(150,200,250mg/kgorallyeveryalternatedayfor21days)reducestumorgrowthby50%intheS-180solidtumormousemodel,inhibitsoxidationinnormalliver,andpromotesoxidationintumortissue[6].REFERENCESOnerZ1,etal.Theprotectiveandtherapeuticeffectsoflinaloolagainstdoxorubicin-inducedcardiotoxicityinWistaralbinorats.HumExpToxicol.2019Apr12:960327119842634.JanaS,etal.Antitumorigenicpotentialoflinaloolisaccompaniedbymodulationofoxidativestress:aninvivostudyinsarcoma-180solidtumormodel.NutrCancer.2014;66(5):835-48.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEJunHJ,etal.LinaloolisaPPARαligandthatreducesplasmaTGlevelsandrewiresthehepatictranscriptomeandplasmametabolome.JLipidRes.2014Jun;55(6):1098-110.Rodenak-KladniewB,etal.Anti-cancermechanismsoflinalooland1,8-cineoleinnon-smallcelllungcancerA549cells.Heliyon.2020Dec15;6(12):e05639.AnQ,etal.Recentupdatesonbioactivepropertiesoflinalool.FoodFunct.2021Nov1;12(21):10370-10389.RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplicati