K34c-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEK34chydrochlorideCat.No.:HY-150124ACASNo.:2986315-25-5分⼦式:C₂₆H₃₀ClN₃O₄分⼦量:483.99作⽤靶点:Integrin;Apoptosis作⽤通路:Cytoskeleton;Apoptosis储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:125mg/mL(258.27mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.0662mL10.3308mL20.6616mL5mM0.4132mL2.0662mL4.1323mL10mM0.2066mL1.0331mL2.0662mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性K34chydrochloride⼀种有效的、选择性α5β1integrin拮抗剂。K34chydrochloride抑制α5β1integrin可减轻化疗诱导的细胞过早衰⽼，并促进细胞凋亡(Apoptosis)。K34chydrochloride可⽤于胶质母细胞瘤研究[1]。体外研究K34c(20μM;24or48h)significantlyinducesU87MGcellsapoptosisincombinationwith1μMEllipticine(HY-15753)[1].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEK34c(20μM;48h)significantlydecreasesTemozolomide(HY-17364)-inducedsenescenceincellstransfectedwithcontrolnontargetingsiRNAwithoutaffectingsignificantlytheresidualsenescenceofcellstransfectedwithsiRNAspecificforp53[1].REFERENCES[1].MartinkovaE,etal.alpha5beta1integrinantagonistsreducechemotherapy-inducedprematuresenescenceandfacilitateapoptosisinhumanglioblastomacells.IntJCancer.2010Sep1;127(5):1240-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955