IRW-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEIRWCat.No.:HY-P11358CASNo.:159718-10-2分子式:C₂₃H₃₅N₇O₄分子量:473.57Sequence:Ile-Arg-TrpSequenceShortening:IRW作用靶点: Angiotensin-convertingEnzyme(ACE);Acetyl-CoACarboxylase;MitochondrialMetabolism作用通路: MetabolicEnzyme/Protease储存方式: PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性IRW是一种从蛋清中提取的具有口服活性的三肽，具有血管紧张素转换酶(ACE)抑制特性。IRW可通过调节肝脏脂质代谢和增加线粒体含量，预防高脂饮食(HFD)诱导的非酒精性脂肪肝(NAFLD)。IRW能降低肝脏甘油三酯含量和脂滴大小。IRW可增加肝脏线粒体复合物和柠檬酸合酶活性、5'-AMP激活蛋白激酶的磷酸化以及微粒体甘油三酯转移蛋白的丰度。IRW能增加磷酸化的乙酰辅酶A羧化酶(acetylCoAcarboxylase)和线粒体复合物，可用于炎症相关研究[1]。体内研究IRW(45mg/kg,p.o.,dailyfor8weeks)preventsHFD-inducednon-alcoholicfattyliverdisease(NAFLD)ineC57BL/6micewithhigh-fatdiet(HFD)[1].AnimalModel:C57BL/6micewithhigh-fatdiet(HFD)[1]Dosage:45mg/kg,dietAdministration:Orallyadministration,dailyfor8weeksResult:Decreasedhepatictriglyceridecontentandlipiddropletsize.Increasedtheabundanceofhepaticmitochondrialcomplexes(Ⅰ-Ⅴ)andcitratesynthaseactivity.Improvedglucosetoleranceandreducedfastingbloodglucose.Decreasedbodyweightgainandenhancedhepaticphosphorylatedacetyl-CoA1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEcarboxylase(p-ACC)levels.Increasedadiponectincontentinretroperitonealwhiteadiposetissue(rWAT).REFERENCESStephenyC.etal.IRWimprovesdiet-inducednon-alcoholicfattyliverdiseasebyreducingsteatosisassociatedwithincreasedcapacityforoxidativephosphorylation,JournalofFunctionalFoods,Volume112,2024,105976,ISSN1756-4646McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021