ON-01500-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEON01500Cat.No.:HY-78883CASNo.:592542-50-2分子式:C₁₉H₂₃NO₆S分子量:393.45作用靶点:Microtubule/Tubulin作用通路:CellCycle/DNADamage;Cytoskeleton储存方式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验 H2O:<0.1mg/mL(insoluble)请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。BIOLOGICALACTIVITY生物活性ON01500是一种tubulin抑制剂，其Kd值为21nM。ON01500在细胞中发挥微管解聚作用。ON01500可用于癌症研究[1][2]。体外研究ON01500(1μM)completelyinhibitstubulinpolymerizationinMAP-richtubulinsamples[1].ON01500(7-15nM,3-5days)sensitizescellstoknockdownofTACC3oroverexpressionofKIF2CandprotectscellsfromoverexpressionofTACC3orknockdownofKIF2C,withhightoxicity[2].ON01500(10nM,3-7days)inducesenrichmentofL240FTUBB-expressing(mCherry-positive)K562cellsrelativetowild-typecells[2].REFERENCES[1].BakerSJ,etal.AContaminantImpurity,NotRigosertib,IsaTubulinBindingAgent.MolCell.2020Jul2;79(1):180-190.e4.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEJost,Marcoetal.Pharmaceutical-GradeRigosertibIsaMicrotubule-DestabilizingAgent.MolecularCell,Volume79,Issue1,191-198.e3McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021