Anti-inflammatory-agent-107-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAnti-inflammatoryagent107Cat.No.:HY-179502分⼦式:C₂₉H₂₀N₆O₉S分⼦量:628.57作⽤靶点:NF-κB;GlutathionePeroxidase;TNFReceptor;InterleukinRelated;mTOR;SOD作⽤通路:NF-κB;Apoptosis;MetabolicEnzyme/Protease;Immunology/Inflammation;PI3K/Akt/mTOR储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Anti-inflammatoryagent107⼀种⼝服有效的抗炎剂。Anti-inflammatoryagent107能够以-9.4578kcal/mol的优异结合亲和⼒抑制NF-κB。Anti-inflammatoryagent107降低了抗炎因⼦(TNF-α，IL-6，INF-γ，NF-κβ，CRP(C反应蛋⽩)和ESR(红细胞沉降率)(ErythrocyteSedimentationRate))的含量并且提升SOD(超氧化物歧化酶),CAT(过氧化氢酶)和GSH(⾕胱⽢肽)的活性来增强内性抗氧化防御系统。Anti-inflammatoryagent107⽆肝肾毒性并且展现出显著的肝肾保护作⽤。Anti-inflammatoryagent107能剂量依赖性地改⽩细胞浸润和组织⽔肿。Anti-inflammatoryagent107可⽤于抗炎研究[1]。IC50&TargetNF-κBIL-6mTOR体外研究Anti-inflammatoryagent107(compound4D)exertsapowerfulanti-inflammatorybysuppressingNF-κβwithadockingscoreof9.4578kcal/mol,theprimaryinflammatoryproteinsignaling[1].Anti-inflammatoryagent107(50μg/mLin2mL,50μg/mLin0.02mL)showspotentanti-inflammatoryactivityinboththehumanredbloodcellmembranestabilization(anti-hemolytic)assayandtheproteindenaturationinhibitionassay[1].体内研究Anti-inflammatoryagent107(compound4D)(20-50μg/kg,p.o.,oncedailyforaweek)reduceinflammatorybiomarkers,enhancesandrestorestheantioxidantdefenses(GSH,CAT,SOD)andrenaltoxicity,andreducesleukocyteinfiltrationinκ-Carrageenan(HY-138962)-inducedpawedemarats[1].AnimalModel:κ-Carrageenan(0.1mLof1%W/V,injectintothesubplantarregionoftherighthindpaw,once)-inducedmale(SpragueDawley)rats(120-125g,6-8weeks)[1].Dosage:20,30and50μg/kg1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAdministration:p.o.,oncedailyforaweekResult:Showedgraduallyimprovementatdifferentdoses.Showedgraduallyimprovement,gaveverycloseresultscomparetoaspirinat30μg/kg.Reducedlevelsofinflammatorybiomarkers(TNF-α,IL-6,INF-γ,NF-κβ,CRPandESR)athehigh-dose50μg/kg.Showedexcellentmalondialdehyde(MDA)andnitricoxide(NO)improvementespeciallyat30and50μg/kg.ReducedGSHconcentrations,returnedCATandSODactivitiestonearlynormalranges.Showedgoodregressioninhepaticenzymesecretion,totalbilirubinconjugationandexcretion,andalbuminbiosynthesis.Reversedthecarrageenan-inducedrenaltoxicity(characterizedbyincreasedureaandcreatinine)andrestoredtheseparameterstonear-normalranges.Produceddose-dependentimprovementsinhistopathology,reducingleukocyteinfiltrationatlowerdosesandnearlyeliminatingedemawhilerestoringnormalskinarchitectureatthehighestdose(50μg/kg).REFERENCES[1].RizkHF,etal.Newlysynthesizedpyranopyrazolenicotinamidesderivativesaspotentanti-inflammatoryagents:In-silico,in-vitro,andin-vivostudies.BioorgChem.2025Dec;167:109205.McePdfHeightCaution:Producthasnotbeenfullyvalidatedfo