Avanafil-metabolite-M4-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAvanafilmetaboliteM4Cat.No.:HY-179550CASNo.:2656442-91-8分⼦式:C₂₃H₂₆ClN₇O₄分⼦量:499.95作⽤靶点:DrugMetabolite;Phosphodiesterase(PDE);PKG作⽤通路:MetabolicEnzyme/Protease;StemCell/Wnt储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性AvanafilmetaboliteM4(CompoundM-4ii)⼀种Avanafil(HY-18252)代谢物。Avanafil⼀种选择性磷酸⼆酯酶-5(PDE-5)抑制剂，对PDE-5、PDE-6、PDE-4、PDE-10、PDE-8、PDE-7、PDE-2和PDE-1的IC50分别为5.2nM、630nM、5700nM、6200nM、12000nM、27000nM、51000nM和53000nM。Avanafil通过激活NO/cGMP/PKG信号通路来减少⾻密度下降、⾻萎缩和氧化应激。Avanafil抑制cGMP⽔解，从⽽提⾼cGMP⽔平。Avanafil可⽤于研究勃起功能障碍和⾻质疏松症[1][2][3][4]。REFERENCES[1].KammounAK,etal.LC-MS/MSdeterminationofavanafilanditsmetabolitesinratplasmaandbrain:pharmacokineticstudyafteroraladministrationandtransdermalfilmapplication.RSCAdv.2020Mar4;10(16):9407-9413.[2].HuyutZ,etal.EffectsofthePhosphodiesterase-5(PDE-5)Inhibitors,AvanafilandZaprinast,onBoneRemodelingandOxidativeDamageinaRatModelofGlucocorticoid-InducedOsteoporosis.MedSciMonitBasicRes.2018Mar13;24:47-58.[3].YilmazD,et,al.Theeffectofintracavernosalavanafil,anewerphosphodiesterase-5inhibitor,onneonataltype2diabeticratswitherectiledysfunction.Urology.2014Feb;83(2):508.e7-12.[4].KoteraJ,et,al.Avanafil,apotentandhighlyselectivephosphodiesterase-5inhibitorforerectiledysfunction.JUrol.2012Aug;188(2):668-74.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955