E722-2648-TFA-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEE722-2648TFACat.No.:HY-148918A分⼦式:C₂₃H₃₁F₃N₂O₃S₂分⼦量:504.63作⽤靶点:β-catenin;Wnt作⽤通路:StemCell/Wnt储存⽅式:-20°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性数据体外实验DMSO:100mg/mL(198.16mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.9816mL9.9082mL19.8165mL5mM0.3963mL1.9816mL3.9633mL10mM0.1982mL0.9908mL1.9816mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(4.95mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性E722-2648TFA⼀种有效的β-catenin/BCL9复合物抑制剂。E722-2648TFA特异性抑制β-catenin/BCL9复合物的形成和Wnt活性。E722-2648TFA通过增加胆醇酯化和脂滴积累破坏胆醇稳态。E722-2648TFA具有抗肿瘤活性。REFERENCES[1].TantonH,etal.Anovelβ-catenin/BCL9complexinhibitorblocksoncogenicWntsignalinganddisruptscholesterolhomeostasisincolorectalcancer.SciAdv.2022Apr29;8(17):eabm3108.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792