Gemcitabine-13C-15N2-LY-188011-sup-13-sup-C-sup-15-sup-N-sub-2-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGemcitabine-13C,15N2Cat.No.:HY-17026SCASNo.:1233921-74-8Synonyms:LY188011-13C,15N2分⼦式:C₈₁₃CH₁₁F₂N₁₅N₂O₄分⼦量:266.18作⽤靶点:Isotope-LabeledCompounds;NucleosideAntimetabolite/Analog;DNA/RNASynthesis;Autophagy;Apoptosis作⽤通路:Others;CellCycle/DNADamage;Autophagy;Apoptosis储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)BIOLOGICALACTIVITY⽣物活性Gemcitabine-13C,15N2(LY188011-13C,15N2)13C和15N标记的Gemcitabine(HY-17026)。Gemcitabine(LY188011)⼀种嘧啶核苷类似物抗代谢药(nucleosideantimetabolite/analog)和抗肿瘤剂。Gemcitabine抑制DNA合成(DNAsynthesis)和修复，导致细胞⾃噬(autophagy)和凋亡(apoptosis)。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].WangH,etal.EnhancedefficacyofGemcitabinebyindole-3-carbinolinpancreaticcelllines:theroleofhumanequilibrativenucleosidetransporter1.AnticancerRes.2011Oct;31(10):3171-80.[2].GagnadouxF,etal.Safetyofpulmonaryadministrationofgemcitabineinrats.JAerosolMed.2005Summer;18(2):198-206.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0