HBX-41108-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEHBX41108(Standard)Cat.No.:HY-101666RCASNo.:924296-39-9分⼦式:C₁₃H₃ClN₄O分⼦量:266.64作⽤靶点:Deubiquitinase;ReferenceStandards;Apoptosis;MDM-2/p53作⽤通路:CellCycle/DNADamage;Others;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性HBX41108(Standard)HBX41108(HY-101666)的分析标准品。本产品⽤于研究及分析应⽤。HBX41108泛素特异性蛋⽩酶7(USP7)的抑制剂，IC50为424nM。HBX41108抑制USP7介导的p53去泛素化以稳定p53并抑制癌细胞⽣长。HBX41108可⽤于癌症和糖尿病的研究[1][2][3]REFERENCES[1].CollandF,etal.Small-moleculeinhibitorofUSP7/HAUSPubiquitinproteasestabilizesandactivatesp53incells.MolCancerTher.2009Aug;8(8):2286-95.[2].ColomboM,etal.Synthesisandbiologicalevaluationof9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrileanaloguesaspotentialinhibitorsofdeubiquitinatingenzymes.ChemMedChem.2010Apr6;5(4):552-8.[3].LiX,WangT,etal.InhibitionofUSP7suppressesadvancedglycationend-inducedcellcyclearrestandsenescenceofhumanumbilicalveinendothelialcellsthroughubiquitinationofp53.ActaBiochimBiophysSin(Shanghai).2022Mar25;54(3):311-320.[4].LiX,WangT,etal.InhibitionofUSP7suppressesadvancedglycationend-inducedcellcyclearrestandsenescenceofhumanumbilicalveinendothelialcellsthroughubiquitinationofp53.ActaBiochimBiophysSin(Shanghai).2022Mar25;54(3):311-320.[5].NawaY,etal.Functionalcharacterizationoftheneuron-restrictivesilencerelementinthehumantryptophanhydroxylase2geneexpression.JNeurochem.2017Sep;142(6):827-840.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-