【龙脑与抗菌的研究文献综述2300字】

龙脑与抗菌的研究文献综述1.1龙脑龙脑（C10H18O）是一种双环单萜醇，从龙脑香科植物的树脂或精油产品中提取并结晶，是一种脂溶性分子，分子量小ADDINEN.CITE<EndNote><Cite><Author>Meng</Author><Year>2019</Year><RecNum>113</RecNum><DisplayText><styleface="superscript">[65]</style></DisplayText><record><rec-number>113</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610893096">113</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Meng,Lingwei</author><author>Chu,Xiaoyang</author><author>Xing,Haoyue</author><author>Liu,Xuan</author><author>Xin,Xin</author><author>Chen,Liqing</author><author>Jin,Mingji</author><author>Guan,Youyan</author><author>Huang,Wei</author><author>Gao,Zhonggao</author></authors></contributors><titles><title>Improvingglioblastomatherapeuticoutcomesviadoxorubicin-loadednanomicellesmodifiedwithborneol</title><secondary-title>InternationalJournalofPharmaceutics</secondary-title></titles><periodical><full-title>InternationalJournalofPharmaceutics</full-title></periodical><pages>118485</pages><volume>567</volume><section>118485</section><dates><year>2019</year></dates><isbn>03785173</isbn><urls></urls><electronic-resource-num>10.1016/j.ijpharm.2019.118485</electronic-resource-num></record></Cite></EndNote>[65]，天然精油提取的主要成分为龙脑，合成龙脑还包含大量的异龙脑（龙脑的差向异构体）。龙脑作为日化行业广泛使用的香料成分，2008年统计数据显示全球每年的使用量已经达到10-100公吨ADDINEN.CITE<EndNote><Cite><Author>Bhatia</Author><Year>2008</Year><RecNum>108</RecNum><DisplayText><styleface="superscript">[66]</style></DisplayText><record><rec-number>108</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610887733">108</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Bhatia,S.P.</author><author>Letizia,C.S.</author><author>Api,A.M.</author></authors></contributors><titles><title>Fragrancematerialreviewonborneol</title><secondary-title>FoodandChemicalToxicology</secondary-title></titles><periodical><full-title>FoodandChemicalToxicology</full-title></periodical><pages>S77-S80</pages><volume>46</volume><number>11</number><section>S77</section><dates><year>2008</year></dates><isbn>02786915</isbn><urls></urls><electronic-resource-num>10.1016/j.fct.2008.06.031</electronic-resource-num></record></Cite></EndNote>[66]。同时，作为传统中药复兴的代表，临床使用已经超过1500年ADDINEN.CITEADDINEN.CITE.DATA[67,68]，它在药物实验中被发现能够促进许多皮肤外用药的促皮渗透，还可以改善药物的鼻、口腔和胃肠道对药物的利用效率，加速血脑平展（BBB）的开放，显著增强用药疗效ADDINEN.CITE<EndNote><Cite><Author>Lu</Author><Year>2011</Year><RecNum>105</RecNum><DisplayText><styleface="superscript">[69]</style></DisplayText><record><rec-number>105</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610887575">105</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Lu,Yang</author><author>Du,Shou-ying</author><author>Chen,Xiao-lan</author><author>Wu,Qing</author><author>Song,Xiao</author><author>Xu,Bing</author><author>Zhai,Yong-song</author></authors></contributors><titles><title>Enhancingeffectofnaturalborneolontheabsorptionofgeniposideinratviaintranasaladministration</title><secondary-title>JournalofZhejiangUniversitySCIENCEB</secondary-title></titles><periodical><full-title>JournalofZhejiangUniversitySCIENCEB</full-title></periodical><pages>143-148</pages><volume>12</volume><number>2</number><section>143</section><dates><year>2011</year></dates><isbn>1673-1581 1862-1783</isbn><urls></urls><electronic-resource-num>10.1631/jzus.B1000121</electronic-resource-num></record></Cite></EndNote>[69]。许多研究表明它还具有其他几种药理学活性，包括镇痛、抗炎、抗氧化和抗菌效果ADDINEN.CITEADDINEN.CITE.DATA[70-75]。龙脑作为一种珍贵的天然活性物质，展示出了广谱抗菌的效果。例如，Aline等人利用微波辅助合成法制备了一系列龙脑酯衍生物，其中Bornyl-3′,4′-dimethoxybenzoate针对测试中用到的所有种类细菌和真菌都显示出抗菌活性ADDINEN.CITE<EndNote><Cite><Author>eSilva</Author><Year>2017</Year><RecNum>114</RecNum><DisplayText><styleface="superscript">[76]</style></DisplayText><record><rec-number>114</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610939275">114</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>eSilva,AlineTeixeiraMaciel</author><author>Pereira,ViníciusViana</author><author>Takahashi,JacquelineAparecida</author><author>Silva,RoquelineRodrigues</author><author>Duarte,LucienirPains</author></authors></contributors><titles><title>Microwave-assistedsynthesisofborneolestersandtheirantimicrobialactivity</title><secondary-title>NaturalProductResearch</secondary-title></titles><periodical><full-title>NaturalProductResearch</full-title></periodical><pages>1714-1720</pages><volume>32</volume><number>14</number><section>1714</section><dates><year>2017</year></dates><isbn>1478-6419 1478-6427</isbn><urls></urls><electronic-resource-num>10.1080/14786419.2017.1399380</electronic-resource-num></record></Cite></EndNote>[76]。更重要的点在于从这篇文章中可以得到一个非常关键的结论，即龙脑及其衍生物的抗菌效果并不依赖于龙脑分子上的羟基，而是龙脑本身独特的双环单萜结构与手性共同作用的结果，这一结论给龙脑在抗菌领域更广泛的应用提供了充分的想象空间。图1-4不同旋光性龙脑分子结构图ADDINEN.CITE<EndNote><Cite><Author>Wu</Author><Year>2018</Year><RecNum>120</RecNum><DisplayText><styleface="superscript">[77]</style></DisplayText><record><rec-number>120</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1611042209">120</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Wu,Jianhui</author><author>Wang,Chunhua</author><author>Mu,Changdao</author><author>Lin,Wei</author></authors></contributors><titles><title>Awaterbornepolyurethanecoatingfunctionalizedbyisobornylwithenhancedantibacterialadhesionandhydrophobicproperty</title><secondary-title>EuropeanPolymerJournal</secondary-title></titles><periodical><full-title>EuropeanPolymerJournal</full-title></periodical><pages>498-506</pages><volume>108</volume><section>498</section><dates><year>2018</year></dates><isbn>00143057</isbn><urls></urls><electronic-resource-num>10.1016/j.eurpolymj.2018.09.034</electronic-resource-num></record></Cite></EndNote>[77]Figure.1-4Molecularstructurediagramofborneolwithdifferentopticalrotation1.2龙脑基抗菌材料鉴于龙脑较强的生物活性，将其与其他抗菌体系结合，从而发挥更好的效果，成为研究者深入思考的方向。龙脑在应用上存在水溶性差和易挥发的缺点，Xiao-YanLi等利用龙脑与PVP之间的氢键作用，通过电纺法制备了纳米复合纤维，有效克服了龙脑本身的缺点ADDINEN.CITE<EndNote><Cite><Author>Li</Author><Year>2012</Year><RecNum>115</RecNum><DisplayText><styleface="superscript">[78]</style></DisplayText><record><rec-number>115</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610957898">115</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Li,Xiao-Yan</author><author>Wang,Xia</author><author>Yu,Deng-Guang</author><author>Ye,Shuai</author><author>Kuang,Qi-Kun</author><author>Yi,Qing-Wen</author><author>Yao,Xin-Zhe</author></authors></contributors><titles><title>ElectrospunBorneol-PVPNanocomposites</title><secondary-title>JournalofNanomaterials</secondary-title></titles><periodical><full-title>JournalofNanomaterials</full-title></periodical><pages>1-8</pages><volume>2012</volume><section>1</section><dates><year>2012</year></dates><isbn>1687-4110 1687-4129</isbn><urls></urls><electronic-resource-num>10.1155/2012/731382</electronic-resource-num></record></Cite></EndNote>[78]。Wangxing课题组针对龙脑复合体系抗菌机理及应用的研究最为详尽。与现存诸多抗菌研究的内在机理主要通过与微生物磷脂双分子层相互作用从而破坏细胞膜完整性或是影响细菌正常功能的毒害模式不同，他们别出心裁提出利用细菌细胞对材料界面的“感觉”，从而选择自己是否依附在该材料表面，利用这一与众不同的立体化学策略设计抗细菌粘附的聚合物ADDINEN.CITE<EndNote><Cite><Author>Luo</Author><Year>2014</Year><RecNum>116</RecNum><DisplayText><styleface="superscript">[79]</style></DisplayText><record><rec-number>116</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610978287">116</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Luo,Lingqiong</author><author>Li,Guofeng</author><author>Luan,Di</author><author>Yuan,Qipeng</author><author>Wei,Yen</author><author>Wang,Xing</author></authors></contributors><titles><title>AntibacterialAdhesionofBorneol-BasedPolymerviaSurfaceChiralStereochemistry</title><secondary-title>ACSAppliedMaterials&Interfaces</secondary-title></titles><periodical><full-title>ACSAppliedMaterials&Interfaces</full-title></periodical><pages>19371-19377</pages><volume>6</volume><number>21</number><section>19371</section><dates><year>2014</year></dates><isbn>1944-8244 1944-8252</isbn><urls></urls><electronic-resource-num>10.1021/am505481q</electronic-resource-num></record></Cite></EndNote>[79]。真菌是一种真核生物，相较于细菌，在新陈代谢和细胞结构上与哺乳动物细胞更相似，因此许多具有良好抗真菌效果的材料也显示出较强的细胞毒性，ShiBing等将龙脑共价接枝到纤维素上，实验结果表面，经过修饰后的纤维素在抗真菌粘附和抑制生长方面有着出色的表现，所使用的左旋龙脑与纤维素都是安全易得且具有良好的生物相容性，有望成为新一代抗真菌医用材料ADDINEN.CITE<EndNote><Cite><Author>Shi</Author><Year>2015</Year><RecNum>119</RecNum><DisplayText><styleface="superscript">[80]</style></DisplayText><record><rec-number>119</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610980115">119</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Shi,Bing</author><author>Luan,Di</author><author>Wang,Shihui</author><author>Zhao,Lingyun</author><author>Tao,Lei</author><author>Yuan,Qipeng</author><author>Wang,Xing</author></authors></contributors><titles><title>Borneol-graftedcelluloseforantifungaladhesionandfungalgrowthinhibition</title><secondary-title>RSCAdvances</secondary-title></titles><periodical><full-title>RSCAdvances</full-title></periodical><pages>51947-51952</pages><volume>5</volume><number>64</number><section>51947</section><dates><year>2015</year></dates><isbn>2046-2069</isbn><urls></urls><electronic-resource-num>10.1039/c5ra07894f</electronic-resource-num></record></Cite></EndNote>[80]。氧化石墨烯及其衍生物通过物理结构（锋利的边缘）和催化产生ROS等机理对微生物细胞膜的磷脂双分子层也能产生破坏作用。LiGuofeng等利用巯丁二酸作为连接分子，赋予氧化石墨烯表面丰富的羧基，随后通过简单的酯化反应，将龙脑接枝在氧化石墨烯表面制备而成的复合材料，共价键固定的龙脑分子避免了在使用环境下的脱落，显示了长效抗真菌效果(图1-5)。对抗真菌机理深入研究后发现，传统的理论并不适用于氧化石墨烯-龙脑复合体系.首先，石墨烯及其衍生物本身对真菌是不具备抑制或杀灭效果的；其次，丝状真菌生命力顽强，可以从任意一个孢子生长得到；最后，从微生物自身来说，菌丝（200μm）的尺寸远大于细菌（1-3μm），大到足够抵御针状纳米结构所带来的破坏。因此，龙脑复合体系抗真菌的机理可能包含几个步骤，先是拥有复杂碳原子立体化学的笼型龙脑分子可以极大的降低微生物在材料表面的附着，与此同时，链接基团有助于龙脑分子均匀固定在材料表面。一方面，龙脑作为疏水性小分子可以与膜结构发生相互作用，造成微生物的死亡；另一方面，真菌能够主动避开拥有复杂碳立体化学结构的表面，二者的协同作用带来了出色的抗真菌效果ADDINEN.CITE<EndNote><Cite><Author>Li</Author><Year>2017</Year><RecNum>121</RecNum><DisplayText><styleface="superscript">[81]</style></DisplayText><record><rec-number>121</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1611042231">121</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Li,Guofeng</author><author>Zhao,Hongjuan</author><author>Hong,Jie</author><author>Quan,Kecheng</author><author>Yuan,Qipeng</author><author>Wang,Xing</author></authors></contributors><titles><title>Antifungalgrapheneoxide-borneolcomposite</title><secondary-title>ColloidsandSurfacesB:Biointerfaces</secondary-title></titles><periodical><full-title>ColloidsandSurfacesB:Biointerfaces</full-title></periodical><pages>220-227</pages><volume>160</volume><section>220</section><dates><year>2017</year></dates><isbn>09277765</isbn><urls></urls><electronic-resource-num>10.1016/j.colsurfb.2017.09.023</electronic-resource-num></record></Cite></EndNote>[81]。图1-5氧化石墨烯-龙脑复合体系ADDINEN.CITE<EndNote><Cite><Author>Li</Author><Year>2017</Year><RecNum>121</RecNum><DisplayText><styleface="superscript">[81]</style></DisplayText><record><rec-number>121</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1611042231">121</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Li,Guofeng</author><author>Zhao,Hongjuan</author><author>Hong,Jie</author><author>Quan,Kecheng</author><author>Yuan,Qipeng</author><author>Wang,Xing</author></authors></contributors><titles><title>Antifungalgrapheneoxide-borneolcomposite</title><secondary-title>ColloidsandSurfacesB:Biointerfaces</secondary-title></titles><periodical><full-title>ColloidsandSurfacesB:Biointerfaces</full-title></periodical><pages>220-227</pages><volume>160</volume><section>220</section><dates><year>2017</year></dates><isbn>09277765</isbn><urls></urls><electronic-resource-num>10.1016/j.colsurfb.2017.09.023</electronic-resource-num></record></Cite></EndNote>[81]Figure.1-5Grapheneoxide-borneolcompositesystem精油及其活性成分属于易挥发性物质，可控释放的模式有限。龙脑等天然活性成分分子结构中含有可反应的羟基，并且针对羟基的修饰并不会影响天然物质的活性，反而可能增强ADDINEN.CITE<EndNote><Cite><Author>Dorman</Author><Year>2000</Year><RecNum>207</RecNum><DisplayText><styleface="superscript">[82]</style></DisplayText><record><rec-number>207</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1621752895">207</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Dorman,H.J.D.</author><author>Deans,S.G.</author></authors></contributors><titles><title>Antimicrobialagentsfromplants:antibacterialactivityofplantvolatileoils</title><secondary-title>JournalofAppliedMicrobiology</secondary-title></titles><periodical><full-title>JournalofAppliedMicrobiology</full-title></periodical><pages>308-316</pages><volume>88</volume><number>2</number><dates><year>2000</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1364-5072</isbn><accession-num>WOS:000085947500015</accession-num><urls><related-urls><url><GotoISI>://WOS:000085947500015</url></related-urls></urls><electronic-resource-num>10.1046/j.1365-2672.2000.00969.x</electronic-resource-num></record></Cite></EndNote>[82]，WangXing团队将龙脑制备成可聚合单体，通过自由基聚合，制备了聚龙脑丙烯酸酯，细菌“越狱”实验直观的展示了其优异的抑菌效果，75h后，与对照组PMMA外围布满细菌相比，聚龙脑丙烯酸酯成功抑制了细菌的生长，他们提出抗菌的关键点在于表面的立体化学而不是润湿性ADDINEN.CITE<EndNote><Cite><Author>Luo</Author><Year>2014</Year><RecNum>116</RecNum><DisplayText><styleface="superscript">[79]</style></DisplayText><record><rec-number>116</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1610978287">116</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Luo,Lingqiong</author><author>Li,Guofeng</author><author>Luan,Di</author><author>Yuan,Qipeng</author><author>Wei,Yen</author><author>Wang,Xing</author></authors></contributors><titles><title>AntibacterialAdhesionofBorneol-BasedPolymerviaSurfaceChiralStereochemistry</title><secondary-title>ACSAppliedMaterials&Interfaces</secondary-title></titles><periodical><full-title>ACSAppliedMaterials&Interfaces</full-title></periodical><pages>19371-19377</pages><volume>6</volume><number>21</number><section>19371</section><dates><year>2014</year></dates><isbn>1944-8244 1944-8252</isbn><urls></urls><electronic-resource-num>10.1021/am505481q</electronic-resource-num></record></Cite></EndNote>[79]。接着，依据表面立体化学的设计原则，将龙脑结构引入到传统生物医用高分子PMMA中，针对大肠杆菌（革兰氏阴性）和枯草杆菌（革兰氏阳性），共聚物制备的膜材料随着BA摩尔含量的升高抗菌效果越好，最低抑菌添加量为10%，利用小鼠进行皮下植入实验，测试结果表明P（MMA-co-BA）不但有着独特的抗菌表现，还具备极高的生物相容性ADDINEN.CITE<EndNote><Cite><Author>Sun</Author><Year>2016</Year><RecNum>123</RecNum><DisplayText><styleface="superscript">[83]</style></DisplayText><record><rec-number>123</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1611042308">123</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Sun,Xueli</author><author>Qian,Zhiyong</author><author>Luo,Lingqiong</author><author>Yuan,Qipeng</author><author>Guo,Ximin</author><author>Tao,Lei</author><author>Wei,Yen</author><author>Wang,Xing</author></authors></contributors><titles><title>AntibacterialAdhesionofPoly(methylmethacrylate)ModifiedbyBorneolAcrylate</title><secondary-title>ACSAppliedMaterials&Interfaces</secondary-title></titles><periodical><full-title>ACSAppliedMaterials&Interfaces</full-title></periodical><pages>28522-28528</pages><volume>8</volume><number>42</number><section>28522</section><dates><year>2016</year></dates><isbn>1944-8244 1944-8252</isbn><urls></urls><electronic-resource-num>10.1021/acsami.6b10498</electronic-resource-num></record></Cite></EndNote>[83]。他们还进行了棉布表面接枝龙脑的研究，龙脑-4-甲酰苯甲酸酯通过席夫碱反应与硅烷偶联剂Aps（3­aminopropyltrimethoxysilane）修饰的棉布表面共价连接，制得的棉布对常见的有害细菌和真菌显示了良好的抗菌抗粘附效果，相较于杀菌型材料，龙脑改性后的棉布属于细菌排斥型，阻碍细菌接触表面而不是非选择性将其杀灭，为证明是龙脑赋予棉布表面独特的立体化学特征带来的抗菌性能，实验中合成了非手性棉布表面，细菌实验证实后者并不具备抗菌特性。龙脑修饰的棉布不仅在50次加速洗涤前后抗菌性能没有减弱，而且对人体皮肤的正常菌群无不良影响ADDINEN.CITE<EndNote><Cite><Author>Xu</Author><Year>2019</Year><RecNum>122</RecNum><DisplayText><styleface="superscript">[84]</style></DisplayText><record><rec-number>122</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1611042268">122</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Xu,Jiangqi</author><author>Zhao,Hongjuan</author><author>Xie,Zixu</author><author>Ruppel,Scott</author><author>Zhou,Xiaqing</author><author>Chen,Shuang</author><author>Liang,JunF.</author><author>Wang,Xing</author></authors></contributors><titles><title>StereochemicalStrategyAdvancesMicrobiallyAntiadhesiveCottonTextileinSafeguardingSkinFlora</title><secondary-title>AdvancedHealthcareMaterials</secondary-title></titles><periodical><full-title>AdvancedHealthcareMaterials</full-title></periodical><pages>1900232</pages><volume>8</volume><number>15</number><section>1900232</section><dates><year>2019</year></dates><isbn>2192-2640 2192-2659</isbn><urls></urls><electronic-resource-num>10.1002/adhm.201900232</electronic-resource-num></record></Cite></EndNote>[84]（如图1-6）。龙脑基单体同样被应用到其他聚合物体系中，MengLong等利用龙脑丙烯酸酯单体（ISA）与甲基丙烯酸-2-（二甲氨基）乙酯（DMAEMA）进行共聚，随后部分磺化，得到两性离子基聚（甲基丙烯酸磺基甜菜碱-co-甲基丙烯酸-2-二甲氨基乙酯-co-丙烯酸异冰片酯），共聚物形成的胶体粒子与单宁酸通过电泳沉积法锚定在Ti合金表面，修饰后的表面能够有效抑制大肠杆菌（革兰氏阴性）和金黄色葡萄球菌粘附，同时允许正常细胞粘附和生长，具备优秀的细胞相容性ADDINEN.CITE<EndNote><Cite><Author>Meng</Author><Year>2018</Year><RecNum>124</RecNum><DisplayText><styleface="superscript">[85]</style></DisplayText><record><rec-number>124</rec-number><foreign-keys><keyapp="EN"db-id="w00dtf29j2xe22evdf15zpred52fttprxaad"timestamp="1611042344">124</key><keyapp="ENWeb"db-id="">0</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Meng,Long</author><author>Pan,Kai</author><author>Zhu,Ye</author><author>Wei,Wei</author><author>Li,Xiaojie</author><author>Liu,Xiaoya</author></authors></contributors><titles><title>Zwitterionic-BasedSurfaceviatheCoelectrodepositionofColloidParticlesandTannicAcidwithBacterialResistancebutCellAdhesionProperties</title><secondary-title>ACSBiomaterialsScience&Engineering</secondary-title></titles><periodical><full-title>ACSBiomaterialsScience&Engineering</full-title></periodical><pages>4122-4131</pages><volume>4</volume><number>12</number><section>4122</section><dates><year>2018</year></dates><isbn>2373-9878 2373-9878</isbn><urls></urls><electronic-resource-num>10.1021/acsbiomaterials.8b01239</electronic-resource-num></record></Cite></EndNote>[85]。WuJianhui等制备了龙脑修饰的水性聚氨酯涂料，通过Thiol-Ene迈克尔加成反应将龙脑作为扩链剂引入聚氨酯涂料中，有效解决了龙脑基聚合物缺乏附着力从而易于从基底物表面剥离的问题，有望实现高效持久的防污损目标ADDINEN.CITE<EndNote><Cite><Author>Wu</Author><Year>2018</Year><RecNum>120</RecNum><DisplayText><styleface="superscript">[77]</style></DisplayText><recor