Pyrazine-diazohydroxide-sodium-NSC-361456-sodium-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPyrazinediazohydroxidesodiumCat.No.:HY-19045CASNo.:103829-46-5Synonyms:NSC-361456sodium分⼦式:C₄H₄N₄NaO分⼦量:147.09作⽤靶点:DNA/RNASynthesis作⽤通路:CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Pyrazinediazohydroxide(NSC361456)sodium⼀种抗肿瘤剂，通过活性吡嗪重氮离⼦形成DNA加合物。Pyrazinediazohydroxidesodium可⽤于肾癌、结直肠癌、⿊⾊素瘤和⽩⾎病的研究[1][2]。体内研究Pyrazinediazohydroxide(sodium)(44.5-150mg/kg,i.p.,onceeachonDay12,16,and20)showssignificantlyhighertumorcellkillingeffectonlungmetastasesinLOXmelanomaascitescellsxenograftmicecomparedtoprimarytumors[1].AnimalModel:Femalenudemice(NCr-nu)weresubcutaneously(s.c.)inoculatedwith1×10⁶LOXcells,resultinginspontaneouslungmetastasis[1].Dosage:44.5mg/kg,66.7mg/kg,150mg/kgAdministration:I.p.,onceeachonDay12,16,and20Result:Primarytumor:approximately2.5log10Lungmetastases:approximately4.6log10REFERENCES[1].HarrisonSDJr,etal.Scheduledependence,activityagainstnaturalmetastases,andcross-resistanceofpyrazinediazohydroxide(sodiumsalt,NSC361456)inpreclinicalmodelsinvivo.CancerChemotherPharmacol.1990;25(6):425-9.[2].VogelzangNJ,etal.PhaseIIandpharmacodynamicstudiesofpyrazinediazohydroxide(NSC361456)inpatientswithadvancedrenalandcolorectalcancer.ClinCancerRes.1998Apr;4(4):929-34.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895