Rimegepant-hemisulfate-BMS-927711-hemisulfate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERimegepanthemisulfateCat.No.:HY-15498BCASNo.:1642783-82-1Synonyms:BMS-927711hemisulfate;BHV-3000hemisulfate分⼦式:C₂₈H₂₈F₂N₆O₃·₁/₂H₂SO₄分⼦量:583.6作⽤靶点:CGRPReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Rimegepant(BMS-927711)hemisulfate⼀种强效、⼝服有效的选择性竞争性降钙素因相关肽(CGRP)受体拮抗剂，对hCGRP受体的Ki为0.027nM，IC50为0.14nM。Rimegepanthemisulfate可⽤于偏头痛研究[1][2][3]。户使⽤本产品发表的科研⽂献•Nature.2025Apr;640(8059):802-810.•LancetNeurol.2022Mar;21(3):284-294.•Cell.2025Oct24:S0092-8674(25)01129-8.•CellMetab.2022Dec6;34(12):1999-2017.e10.•BrJPharmacol.2024Jan;181(1):142-161.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].LuoG,etal.Discoveryof(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate(BMS-927711):anoralcalcitoningene-relatedpeptide(CGRP)antagonistinclinicaltrialsfortreatingmigraine.JMedChem.2012Dec13;55(23):10644-51.[2].VladimirCoric,etal.Dualtreatmentofmigraine.WO2022251752.2022-12-29.[3].BlairHA.Rimegepant:AReviewintheAcuteTreatmentandPreventiveTreatmentofMigraine.CNSDrugs.2023Mar;37(3):255-265.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEdoi:10.1007/s40263-023-00988-8.Epub2023Feb4.Erratumin:CNSDrugs.2023Jul;37(7):661.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955