RSM-932A-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemERSM-932A(Standard)Cat.No.:HY-101144RCASNo.:850807-63-5分子式:C₄₆H₃₈Br₂Cl₂N₄分子量:877.53作用靶点:CholineKinase;ReferenceStandards作用通路:NeuronalSignaling;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性RSM-932A(Standard)是RSM-932A(HY-101144)的分析标准品。本产品用于研究及分析应用。RSM-932A(TCD-717)是一种特异性ChoKα抑制剂，对人重组ChoKα和ChoKβ酶的IC50分别为1和33μM。RSM-932A是针对ChoKα的“人类首创”化合物。RSM-932A具有有效的体外抗肿瘤增殖和体内抗肿瘤活性，且显示低毒性[1][2]IC50&TargetChoKα[1]REFERENCESJuanCarlosLacal,etal.PreclinicalcharacterizationofRSM-932A,anovelanticancerdrugtargetingthehumancholinekinasealpha,anenzymeinvolvedinincreasedlipidmetabolismofcancercells.MolCancerTher.2015Jan;14(1):31-9.AnadelaCueva,etal.Combined5-FUandChoKαinhibitorsasanewalternativetherapyofcolorectalcancer:evidenceinhumantumor-derivedcelllinesandmousexenografts.PLoSOne.2013Jun10;8(6):e64961.TahlZimmerman,etal.IdentificationandvalidationofnovelandmoreeffectivecholinekinaseinhibitorsagainstStreptococcuspneumonia.SciRep.2020Sep22;10(1):15418.TahlZimmerman,etal.AntiplasmodialactivityandmechanismofactionofRSM-932A,apromisingsynergisticinhibitorofPlasmodiumfalciparumcholinekinase.AntimicrobAgentsChemother.2013Dec;57(12):5878-88.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fa