Sp-cAMPS-sodium-salt-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemESp-cAMPSsodiumsalt(Standard)Cat.No.:HY-100530CRCASNo.:142439-95-0分子式:C₁₀H₁₁N₅NaO₅PS分子量:367.25作用靶点:PKA;ReferenceStandards;Phosphodiesterase(PDE)作用通路:StemCell/Wnt;TGF-beta/Smad;Others;MetabolicEnzyme/Protease储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Sp-cAMPS(sodiumsalt)(Standard)是Sp-cAMPS(sodiumsalt)(HY-100530C)的分析标准品。本产品用于研究及分析应用。Sp-cAMPSsodiumsalt，一种cAMP类似物，是一种依赖cAMP的PKAI和PKAII的有效激活剂。Sp-cAMPSsodiumsalt还是一种有效的竞争性磷酸二酯酶(PDE3A)抑制剂，Ki为47REFERENCESSuHHung,etal.AnewnonhydrolyzablereactivecAMPanalog,(Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioateirreversiblyinactivateshumanplateletcGMP-inhibitedcAMPphosphodiesterase.BioorgChem.2002Feb;30(1):16-31.LYWang,etal.RegulationofkainatereceptorsbycAMP-dependentproteinkinaseandphosphatases.Science.1991Sep6;253(5024):1132-5.RonaldJäger,etal.ActivationofPDE10andPDE11phosphodiesterases.JBiolChem.2012Jan6;287(2):1210-9.PAConnelly,etal.Astudyofthemechanismofglucagon-inducedproteinphosphorylationinisolatedrathepatocytesusing(Sp)-cAMPSand(Rp)-cAMPS,thestimulatoryandinhibitorydiastereomersofadenosinecyclic3',5'-phosphorothioate.JBiolChem.1987Mar25;262(9):4324-32.GDominguez,etal.RescuingprefrontalcAMP-CREBpathwayreversesworkingmemorydeficitsduringwithdrawalfromprolongedalcoholexposure.BrainStructFunct.2016Mar;221(2):865-77.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589