Ticlopidine-d6-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETiclopidine-d6hydrochlorideCat.No.:HY-166530S分⼦式:C₁₄H₉D₆Cl₂NS分⼦量:306.28作⽤靶点:Isotope-LabeledCompounds;CytochromeP450作⽤通路:Others;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Ticlopidine-d6hydrochloride氘代标记的Ticlopidinehydrochloride(HY-B0153A)。Ticlopidine(PCR5332)hydrochloride⼀种抗⾎栓前体，作为⾮竞争性的变构CD39抑制剂，IC50为81.7μM。Ticlopidinehydrochloride阻断NTPDase同⼯酶，对NTPDase2和NTPDase3的IC50分别为170μM和149μM[1]。TiclopidinehydrochlorideCYP2C19⼈肝细胞⾊素的抑制剂。Ticlopidinehydrochloride抑制CYP2C9和CYP3A4，IC50值分别为26.0和32.3μM[2][3]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].LauraSchäkel,etal.2-Substitutedthienotetrahydropyridinederivatives:Allostericectonucleotidaseinhibitors.ArchPharm(Weinheim).2021Dec;354(12):e2100300.[2].I.KRASLOVA1,etal.Ticlopidine-InducedCholestaticInflammatoryHepatitis:NewInsightsintoPathogeneticMechanismsofDrug-RelatedHepatotoxicity.[3].Si-hyungYang,etal.EffectsofticlopidineonpharmacokineticsoflosartananditsmainmetaboliteEXP-3174inrats.ActaPharmacolSin.2011Jul;32(7):967-72.[4].FPiovella,etal.TheeffectofTiclopidineonhumanendothelialcellsinculture.ThrombRes.1984Feb1;33(3):323-32.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-