Tipepidine-citrate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETipepidinecitrateCat.No.:HY-B2185CASNo.:14698-07-8分⼦式:C₂₁H₂₅NO₇S₂分⼦量:467.56作⽤靶点:DopamineReceptor;PotassiumChannel;AMPK作⽤通路:GPCR/GProtein;NeuronalSignaling;MembraneTransporter/IonChannel;Epigenetics;PI3K/Akt/mTOR储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Tipepidinecitrate⼀种⾮⿇醉性镇咳剂。Tipepidinecitrate可逆地抑制多巴胺D2受体(DopamineD2receptor)介导的GIRK电流(IDA(GIRK))，从⽽激活VTA多巴胺神经元，对IDA(GIRK)的IC50为7.0μM。Tipepidinecitrate激活AMPK。Tipepidinecitrate具有抗抑郁样作⽤。Tipepidinecitrate可增强Carbamazepine(HY-B0246)的镇痛作⽤。Tipepidinecitrate改⾼脂饮⾷诱导的肥胖⼩⿏的脂组织纤维化和葡萄糖耐受不良。IC50&TargetD2Receptor户使⽤本产品发表的科研⽂献•ActaPharmacolSin.2025May;46(5):1190-1204.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HamasakiR,etal.TipepidineactivatesVTAdopamineneuronviainhibitingdopamineD₂receptor-mediatedinwardrectifyingKcurrent.Neuroscience.2013Nov12;252:24-34.[2].KawauraK,etal.Tipepidine,anon-narcoticantitussive,exertsanantidepressant-likeeffectintheforcedswimmingtestinadrenocorticotropichormone-treatedrats.BehavBrainRes.2016Apr1;302:269-78.[3].KawauraK,etal.Tipepidineenhancestheantinociceptive-likeactionofcarbamazepineintheaceticacidwrithingtest.EurJPharmacol.2011Jan25;651(1-3):106-8.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[4].SawamotoA,etal.TipepidineactivatesAMPKandimprovesadiposetissuefibrosisandglucoseintoleranceinhigh-fatdiet-inducedobesemice.FASEBJ.2024Mar15;38(5):e23542.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021