Urocortin-III-human-TFA-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEUrocortinIII(human)TFACat.No.:HY-P3019A分⼦式:C₁₈₅H₃₀₇N₅₃O₅₀S₂.xC₂HF₃O₂Sequence:Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-

Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2SequenceShortening:FTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQI-NH2作⽤靶点:CRFR作⽤通路:GPCR/GProtein储存⽅式:Sealedstorage,awayfrommoisturePowder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性UrocortinIII(human)TFA⼀种促肾上腺⽪质激素释放因⼦(CRF)相关肽。UrocortinIII(human)TFA优先结合并激活CRF-R2，在中枢神经系统和外周组织中均有分布。UrocortinIII(human)TFA能强效结合2型CRF受体，特别mCRF2β(Ki=13.5nM)和rCRF2α(Ki=21.7nM)，⽽对hCRF1的亲和⼒极低(Ki>100nM)。UrocortinIII(human)TFA介导⽣长抑素依赖的Insulin(human)(HY-P0035)分泌的负反馈调控[1][2]。IC50&TargetmCRF2βrCRF2α13.5nM(Ki)21.7nM(Ki)体外研究UrocortinIII(human)(0.001-1000nM,20min)FTAinducesintracellularcAMPaccumulationinCHOcellsstablyexpressingmurineCRF-R2[1].REFERENCES[1].LewisK,et,al.IdentificationofurocortinIII,anadditionalmemberofthecorticotropin-releasingfactor(CRF)familywithhighaffinityfortheCRF2receptor.ProcNatlAcadSciUSA.2001Jun19;98(13):7570-5.[2].vanderMeulenT,et,al.Urocortin3mediatessomatostatin-dependentnegativefeedbackcontrolofinsulinsecretion.NatMed.2015Jul;21(7):769-76.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>