WLBU2-acetate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEWLBU2acetateCat.No.:HY-P11085A分⼦式:C₁₅₁H₂₆₀N₆₆O₂₅·xC₂H₄O₂Sequence:Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-ArgSequenceShortening:RRWVRRVRRWVRRVVRVVRRWVRR作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:Sealedstorage,awayfrommoisturePowder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性WLBU2acetate⼀种⼯程阳离⼦抗肽(eCAP)，可克服天然抗肽(AMPs)在环境中的敏感性问题。WLBU2acetate表现出快速杀作⽤，对多种⾰兰⽒阳性和性的MIC值≤l0μM(包括耐甲氧西林⾦⾊葡萄球、耐万古霉素肠球、肺炎克雷伯、产⽓肠杆、沟肠杆、⼤肠埃希等)。WLBU2acetate能阻⽌铜绿假单胞的⽣物膜⽣长，在富含粘液、低pH和⾼盐浓度的环境仍能保持活性，且对⼈类呼吸道上⽪细胞⽆不良响。WLBU2acetate可⽤于研究囊性纤维化(CF)与铜绿假单胞感染。体外研究WLBU2(5-90μM,24h(abioticsurface);10-100μM,5h(CFAECs))acetatepreventsabioticP.aeruginosabiofilmsonanabioticsurfaceandonhumancysticfibrosisairwayepithelialcells(CFAECs)[1].WLBU2(50μM,5h)acetateretainsbiofilmpreventionactivityinhighsalt(100mMNacl)andlowpH(6.5-7.0)environmentsinCFAECs[1].WLBU2(20μM,5h)acetateshowssynergisticeffectwhencombinedwithTobramycin(HY-B0441),ciprofloxacin(HY-B0356),Ceftazidime(HY-B0593),andMeropenem(HY-13678),buthasnosynergisticeffectwithColistin(HY-113678)inCFAECs[1].WLBU2acetateexhibitsaMICvalueof7.943μMagainstKlebsiellapneumoniaeandaMICvalueof7.484μMagainstclinicalisolatesofAcinetobacterbaumannii,withtheMBCvaluesofthebacterialisolatesbeingidenticaltotheirrespectiveMICvalues,indicatingitsbactericidaleffect[2].REFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].LashuaLP,etal.Engineeredcationicantimicrobialpeptide(eCAP)preventsPseudomonasaeruginosabiofilmgrowthonairwayepithelialcells.JAntimicrobChemother.2016Aug;71(8):2200-7.[2].ElsalemL,KhasawnehA,AlSheboulS.WLBU2AntimicrobialPeptideasaPotentialTherapeuticforTreatmentofResistantBacterial.TurkJPharmSci.2022Feb28;19(1):110-116.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: