Y-27632-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEY-27632(Standard)Cat.No.:HY-10071RCASNo.:146986-50-7分子式:C₁₄H₂₁N₃O分子量:247.34作用靶点:Organoid;ROCK;ReferenceStandards;Apoptosis作用通路:StemCell/Wnt;CellCycle/DNADamage;Cytoskeleton;TGF-beta/Smad;Others;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Y-27632(Standard)是Y-27632(HY-10071)的分析标准品。本产品用于研究及分析应用。Y-27632是口服有效的，ATP竞争性的ROCK-I和ROCK-II抑制剂，Ki分别为220nM和300nM。Y-27632减弱阿霉素诱导的人心脏干细胞凋亡(apoptosis)。Y-27632还抑制分离诱导的小鼠前列腺干/祖细胞凋亡。Y-27632通过上皮-间充质过渡样调节引IC50&TargetKi:220/300nM(ROCK-I/II)[1]REFERENCESIshizakiT,etal.PharmacologicalpropertiesofY-27632,aspecificinhibitorofrho-associatedkinases.MolPharmacol.2000May;57(5):976-83.XueZW,etal.Rho-associatedcoiledkinaseinhibitorY-27632promotesneuronal-likedifferentiationofadulthumanadiposetissue-derivedstemcells.ChinMedJ(Engl).2012Sep;125(18):3332-5.InanS,etal.AntiepilepticeffectsoftwoRho-kinaseinhibitors,Y-27632andfasudil,inmice.BrJPharmacol.2008Sep;155(1):44-51.TadaS,etal.AselectiveROCKinhibitor,Y27632,preventsdimethylnitrosamine-inducedhepaticfibrosisinrats.JHepatol.2001Apr;34(4):529-36.MaldonadoM,etal.ROCKinhibitorprimeshumaninducedpluripotentstemcellstoselectivelydifferentiatetowardsmesendodermallineageviaepithelial-mesenchymaltransition-likemodulation.StemCellRes.2016Sep;17(2):222-227.KanL,etal.Rho-AssociatedKinaseInhibitor(Y-27632)AttenuatesDoxorubicin-InducedApoptosisofHumanCardiacStemCells.PLoSOne.2015;10(12):e0144513.Published2015Dec8.ZhangL,etal.ROCKinhibitorY-27632suppressesdissociation-inducedapoptosisofmurineprostatestem/progenitorcellsandincreasestheircloningefficiency.PLoSOne.2011;6(3):e18271.Published2011Mar28.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemESvobodaKK,etal.ROCKinhibitor(Y27632)increasesapoptosisanddisruptstheactincorticalmatinembryonicaviancornealepithelium.DevDyn.2004;229(3):579-590.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonl