WHO骨肿瘤分类剖析课件

WHO(2013)骨肿瘤分类

软骨源性肿瘤(Chondrogenictumor)中间型[局部侵袭性](Intermediate)软骨黏液样纤维瘤(Chondromyxiodfibroma)非典型软骨样肿瘤★/软骨肉瘤(I级)(Atypicalcartilaginoustumor/Chondrosarcoma,gradeI)中间型[偶见转移型](Intermediate)软骨母细胞瘤(Chondroblastoma)恶性(Malignant)软骨肉瘤(II级，III级)(Chondrosarcoma,gradeII,gradeIII)去分化软骨肉瘤(Dedifferentiatedchondrosarcoma)间叶性软骨肉瘤(Mesenchymalchondrosarcoma)透明细胞软骨肉瘤(Clearcellchondrosarcoma)骨源性肿瘤(Osteogenictumor)

良性(Benign)骨瘤(Osteoma)★骨样骨瘤(Osteoidosteoma)中间型[局部侵袭性](Intermediate)骨母细胞瘤(Osteoblastoma)纤维源性肿瘤(Fibrogenictumor)

中间型[局部侵袭性](Intermediate)(骨的)促结缔组织增生性纤维瘤(Desmoplasticfibromaofbone)恶性(Malignant)(骨的)纤维肉瘤(Fibrosarcomaofbone)纤维组织细胞性肿瘤(FibrohistiocyticNeoplasm)

良性纤维组织细胞瘤/非骨化性纤维瘤★(Benignfibroushistocytoma/Non-ossifyingfibroma)造血系统肿瘤

(Haematopoieticneoplasm)

恶性(Malignant)浆细胞骨髓瘤(Plasmacellmyeloma)(骨的)孤立性浆细胞瘤(Solitaryplasmacytomaofbone)(骨的)原发性非霍奇金淋巴瘤

(Primarynon-Hodgkinlymphomaofbone)富于巨细胞的破骨细胞肿瘤(Osteoclasticgiantcell-richtumor)

良性(Benign)小骨的巨细胞病变(Giantcelllesionofthesmallbones)★中间型[局部侵袭性，偶见转移型](骨的)巨细胞肿瘤(Giantcelltumorofbone)恶性(Malignant)骨巨细胞瘤内的恶性(Malignancyingiantcelltumorofbone)脊索样肿瘤(Notochordaltumor)

良性(Benign)良性脊索样细胞瘤(Benignnotochordalcelltumor)★恶性(Malignant)脊索瘤(Chordoma)血管性肿瘤(Vasculartumor)

良性(Benign)血管瘤(Haemangioma)中间型[局部侵袭性，偶见转移型]上皮样血管瘤(Epithelioidhaemangioma)★恶性(Malignant)上皮样血管内皮瘤(Epithelioidhaemangioendothelioma)★血管肉瘤(Angiosarcoma)肌源性肿瘤(Myogenictumor)

良性(Benign)(骨的)平滑肌瘤(Leiomyomaofbone)恶性(Malignant)(骨的)平滑肌肉瘤(Leiomyosarcomaofbone)脂肪源性肿瘤(Lipogenictumor)(骨的)脂肪瘤(Lipomaofbone)(骨的)脂肪肉瘤(Liposarcomaofbone)未明确肿瘤性质的肿瘤

(Tumorofundefinedneoplasticature)

中间型[局部侵袭性]动脉瘤样骨囊肿(Aneurysmalbonecyst)朗格汉斯细胞组织细胞增多症(Langerhanscellhistiocytosis)

单骨型(Monostotic)

多骨型(Polystotic)Erdheim-Chester病(Erdheim-Chesterdisease)杂类肿瘤(Miscellaneoustumor)

尤文肉瘤(Ewingsarcoma)釉质瘤(Adamantinoma)(骨的)未分化高级别多形性肉瘤(Undifferentiatedhighgradepleomorphicsarcomaofbone)附：肿瘤综合征

(Tumorsyndromes)

Bechwith-Wiedemann综合征(Bechwith-Wiedemannsyndrome)家族性巨颌症(Cherubism)★内生软骨瘤病：Ollier病和Maffucci综合征(Enchondromatosis:OllierdiseaseandMaffuccisyndrome)Li-Fraumeni综合征(Li-Fraumenisyndrome)★McCune-Albright综合征(McCune-Albrightsyndrome)多发性骨软骨瘤(Multipleosteochondroma)神经纤维瘤病1型(Neurofibromatosis,type1)视网膜母细胞瘤综合征(Retinoblastomasyndrome)Rothmund-Thomson综合征(Rothmund-Thomsonsyndrome)Werner综合征(Wernersyndrome)Bechwith-Wiedemann：没有命中的记录!Ollier病是一种多发性软骨瘤，病变广泛，并有单侧肢体受累现象，因此骨骼的弯曲，短缩等畸形更为常见。Maffucci是一种以多发性内生软骨瘤合并血管瘤为特征的病变。Li-Fraumeni综合征患者遗传有抑癌基因P53