中药注射剂不良反应及类过敏反应研究进展

中药注射剂不良反应及类过敏反应研究进展一、本文概述Overviewofthisarticle中药注射剂作为中医药现代化的重要成果，近年来在临床上的应用越来越广泛。然而，随着其使用频率的增加，中药注射剂的不良反应及类过敏反应问题也逐渐显现，引起了医学界和公众的广泛关注。本文旨在综述中药注射剂不良反应及类过敏反应的研究进展，为临床安全使用中药注射剂提供参考。TraditionalChinesemedicineinjections,asanimportantachievementinthemodernizationoftraditionalChinesemedicine,havebeenincreasinglywidelyusedinclinicalpracticeinrecentyears.However,withtheincreasingfrequencyofitsuse,theadversereactionsandallergicreactionsoftraditionalChinesemedicineinjectionshavegraduallybecomeapparent,attractingwidespreadattentionfromthemedicalcommunityandthepublic.ThisarticleaimstoreviewtheresearchprogressonadversereactionsandallergicreactionsoftraditionalChinesemedicineinjections,providingreferenceforthesafeuseoftraditionalChinesemedicineinjectionsinclinicalpractice.本文将首先概述中药注射剂不良反应及类过敏反应的基本概念、分类和特点，分析中药注射剂不良反应发生的原因和影响因素。接着，本文将综述近年来国内外关于中药注射剂不良反应及类过敏反应的研究现状，包括不良反应的发生机制、预防措施、诊断方法以及治疗策略等方面的研究进展。本文还将探讨当前研究中存在的问题和争议，以及未来的研究方向和挑战。Thisarticlewillfirstoutlinethebasicconcepts,classifications,andcharacteristicsofadversereactionsandallergicreactionsintraditionalChinesemedicineinjections,andanalyzethecausesandinfluencingfactorsofadversereactionsintraditionalChinesemedicineinjections.Next,thisarticlewillreviewthecurrentresearchstatusonadversereactionsandallergicreactionsoftraditionalChinesemedicineinjectionsbothdomesticallyandinternationallyinrecentyears,includingthemechanismsofadversereactions,preventivemeasures,diagnosticmethods,andtreatmentstrategies.Thisarticlewillalsoexploretheexistingproblemsandcontroversiesincurrentresearch,aswellasfutureresearchdirectionsandchallenges.通过本文的综述，我们期望能够为临床医生和药师提供关于中药注射剂不良反应及类过敏反应的深入了解和全面认识，促进中药注射剂的安全、有效使用，为保障公众健康做出贡献。Throughthereviewinthisarticle,wehopetoprovideclinicaldoctorsandpharmacistswithin-depthandcomprehensiveunderstandingofadversereactionsandallergicreactionsoftraditionalChinesemedicineinjections,promotethesafeandeffectiveuseoftraditionalChinesemedicineinjections,andcontributetoensuringpublichealth.二、中药注射剂不良反应的分类与特点ClassificationandcharacteristicsofadversereactionsintraditionalChinesemedicineinjections中药注射剂作为中医药现代化的重要成果，其临床应用日益广泛。然而，随着使用的普及，其不良反应问题也逐渐显现。中药注射剂的不良反应大致可分为过敏反应、毒性反应、药物热、静脉炎等几类。其中，过敏反应是最常见的不良反应类型，包括速发型过敏反应和迟发型过敏反应。速发型过敏反应通常在注射后立即出现，如荨麻疹、支气管痉挛、过敏性休克等，而迟发型过敏反应则可能在注射后数小时或数天内出现，如皮疹、发热等。AsanimportantachievementinthemodernizationoftraditionalChinesemedicine,traditionalChinesemedicineinjectionsareincreasinglywidelyusedinclinicalpractice.However,withthewidespreaduse,itsadversereactionshavegraduallybecomeapparent.TheadversereactionsoftraditionalChinesemedicineinjectionscanberoughlydividedintoseveralcategories:allergicreactions,toxicreactions,drugfever,phlebitis,etc.Amongthem,allergicreactionsarethemostcommontypesofadversereactions,includingimmediateanddelayedallergicreactions.Instantallergicreactionsusuallyoccurimmediatelyafterinjection,suchasurticaria,bronchospasm,allergicshock,etc.,whiledelayedallergicreactionsmayoccurwithinhoursordaysafterinjection,suchasrash,fever,etc.中药注射剂不良反应的特点主要表现在以下几个方面：一是多样性，不良反应涉及多个系统，如皮肤、呼吸系统、心血管系统等；二是复杂性，由于中药成分的多样性，不良反应的机制往往较为复杂；三是不可预测性，部分不良反应在临床试验中难以预测，增加了用药风险；四是与药物质量、使用剂量、个体差异等因素有关，不同患者可能出现不同的不良反应。ThecharacteristicsofadversereactionsintraditionalChinesemedicineinjectionsaremainlymanifestedinthefollowingaspects:first,diversity,adversereactionsinvolvingmultiplesystems,suchastheskin,respiratorysystem,cardiovascularsystem,etc;Thesecondiscomplexity.DuetothediversityoftraditionalChinesemedicineingredients,themechanismsofadversereactionsareoftenmorecomplex;Thethirdisunpredictability,assomeadversereactionsaredifficulttopredictinclinicaltrials,increasingtheriskofmedicationuse;Thefourthfactorisrelatedtofactorssuchasdrugquality,dosage,andindividualdifferences,anddifferentpatientsmayexperiencedifferentadversereactions.针对中药注射剂的不良反应问题，研究者们进行了大量研究，以期找出其发生机制、影响因素及预防措施。然而，由于中药成分的复杂性，目前对于中药注射剂不良反应的研究仍存在一定的困难。未来，随着中药注射剂在临床的广泛应用，对其不良反应的研究将更加深入，以期提高中药注射剂的安全性和有效性。ResearchershaveconductedextensiveresearchontheadversereactionsoftraditionalChinesemedicineinjectionsinordertoidentifytheirmechanisms,influencingfactors,andpreventivemeasures.However,duetothecomplexityoftraditionalChinesemedicineingredients,therearestillcertaindifficultiesintheresearchofadversereactionsoftraditionalChinesemedicineinjections.Inthefuture,withthewidespreadapplicationoftraditionalChinesemedicineinjectionsinclinicalpractice,researchontheiradversereactionswillbecomemorein-depth,inordertoimprovethesafetyandeffectivenessoftraditionalChinesemedicineinjections.三、中药注射剂类过敏反应的概念与特点TheconceptandcharacteristicsofallergicreactionsintraditionalChinesemedicineinjections中药注射剂类过敏反应是指在使用中药注射剂过程中，人体出现的与药物作用无关的或意外的免疫反应。这种反应与传统的过敏反应相似，但又因其涉及的中药成分复杂性和多样性而具有独特性。类过敏反应的发生机制通常涉及免疫系统的异常激活，可能导致一系列临床症状，如皮疹、瘙痒、呼吸急促、血管神经性水肿等，严重时甚至可能导致休克和死亡。AllergicreactionstotraditionalChinesemedicineinjectionsrefertoimmunereactionsthatoccurinthehumanbodyduringtheuseoftraditionalChinesemedicineinjections,whichareunrelatedtodrugeffectsorunexpected.Thisreactionissimilartotraditionalallergicreactions,butitisuniqueduetothecomplexityanddiversityoftraditionalChinesemedicineingredientsinvolved.Themechanismofallergicreactionsusuallyinvolvesabnormalactivationoftheimmunesystem,whichmayleadtoaseriesofclinicalsymptoms,suchasrash,itching,shortnessofbreath,vascularandneuroedema,andinseverecases,mayevenleadtoshockanddeath.成分复杂性：中药注射剂通常包含多种活性成分，这些成分可能单独或联合引起过敏反应。这种复杂性使得确定具体引起过敏反应的成分变得困难。Ingredientcomplexity:TraditionalChinesemedicineinjectionsusuallycontainmultipleactiveingredients,whichmaycauseallergicreactionsaloneorincombination.Thiscomplexitymakesitdifficulttodeterminethespecificcomponentsthatcauseallergicreactions.反应多样性：中药注射剂类过敏反应的临床表现多种多样，可能涉及皮肤、呼吸系统、心血管系统等多个系统。这种多样性增加了诊断和治疗的难度。Diversityofreactions:TheclinicalmanifestationsofallergicreactionstotraditionalChinesemedicineinjectionsarediverse,andmayinvolvemultiplesystemssuchastheskin,respiratorysystem,andcardiovascularsystem.Thisdiversityincreasesthedifficultyofdiagnosisandtreatment.难以预测：由于中药注射剂成分复杂且作用机制尚未完全明确，因此类过敏反应的发生往往难以预测。这要求在使用中药注射剂时需格外谨慎，密切观察患者的反应。Difficulttopredict:DuetothecomplexcompositionandunclearmechanismofactionoftraditionalChinesemedicineinjections,theoccurrenceofallergicreactionsisoftendifficulttopredict.ThisrequiresextracautionwhenusingtraditionalChinesemedicineinjectionsandcloseobservationofpatientreactions.个体差异性：不同个体对中药注射剂的耐受性存在差异，这可能与个体的遗传背景、免疫系统状态、既往过敏史等因素有关。Individualdifferences:TherearedifferencesinthetoleranceofdifferentindividualstotraditionalChinesemedicineinjections,whichmayberelatedtofactorssuchastheirgeneticbackground,immunesystemstatus,andpastallergyhistory.交叉反应可能性：某些中药注射剂中的成分可能与其他药物或食物存在交叉反应，导致患者在使用这些药物或食物时出现过敏反应。Crossreactivitypossibility:SomecomponentsintraditionalChinesemedicineinjectionsmayhavecrossreactivitywithotherdrugsorfoods,leadingtoallergicreactionsinpatientswhenusingthesedrugsorfoods.中药注射剂类过敏反应具有复杂性、多样性、难以预测性、个体差异性以及交叉反应可能性等特点。因此，在使用中药注射剂时，应充分了解患者的过敏史和药物使用情况，密切观察患者的反应，并采取相应的预防措施以减少过敏反应的发生。还需要进一步深入研究中药注射剂类过敏反应的机制，为临床用药提供更为准确和科学的依据。AllergicreactionstotraditionalChinesemedicineinjectionsarecharacterizedbycomplexity,diversity,unpredictability,individualdifferences,andthepossibilityofcrossreactivity.Therefore,whenusingtraditionalChinesemedicineinjections,itisnecessarytofullyunderstandthepatient'sallergyhistoryandmedicationusage,closelyobservethepatient'sreactions,andtakecorrespondingpreventivemeasurestoreducetheoccurrenceofallergicreactions.Furtherin-depthresearchisneededonthemechanismsofallergicreactionstotraditionalChinesemedicineinjections,inordertoprovidemoreaccurateandscientificbasisforclinicalmedication.四、中药注射剂不良反应及类过敏反应的原因分析AnalysisofthecausesofadversereactionsandallergicreactionsintraditionalChinesemedicineinjections中药注射剂不良反应及类过敏反应的发生，其背后涉及的原因多种多样，这其中包括了药物本身的性质、生产工艺的问题、患者个体差异、用药方式等多个因素。TheoccurrenceofadversereactionsandallergicreactionsintraditionalChinesemedicineinjectionsinvolvesvariousreasons,includingthenatureofthedrugitself,productionprocessissues,individualpatientdifferences,andmedicationmethods.药物本身的性质是决定其是否可能引起不良反应的关键因素。中药材的来源、种类、质量以及提取工艺等都会直接影响中药注射剂的安全性。一些中药材可能含有毒性成分，或者其活性成分在提取过程中未能得到有效控制，这些都可能增加不良反应的风险。中药注射剂中往往含有多种成分，这些成分之间的相互作用也可能引发不良反应。Thenatureofthedrugitselfisakeyfactorindeterminingwhetheritmaycauseadversereactions.Thesource,variety,quality,andextractionprocessoftraditionalChinesemedicinedirectlyaffectthesafetyoftraditionalChinesemedicineinjections.SomeChinesemedicinalmaterialsmaycontaintoxiccomponents,ortheiractiveingredientsmaynotbeeffectivelycontrolledduringtheextractionprocess,whichmayincreasetheriskofadversereactions.TraditionalChinesemedicineinjectionsoftencontainmultiplecomponents,andtheinteractionsbetweenthesecomponentsmayalsocauseadversereactions.生产工艺的问题也是不可忽视的原因。中药注射剂的生产过程包括药材提取、纯化、制剂等多个环节，如果生产过程中的质量控制不严格，可能会导致杂质残留、微生物污染等问题，从而增加不良反应的发生几率。Theissueofproductiontechnologyisalsoanundeniablereason.TheproductionprocessoftraditionalChinesemedicineinjectionsincludesmultiplestagessuchasherbalextraction,purification,andformulation.Ifthequalitycontrolduringtheproductionprocessisnotstrict,itmayleadtoproblemssuchasimpurityresidueandmicrobialcontamination,therebyincreasingtheprobabilityofadversereactions.再者，患者个体差异也是影响中药注射剂不良反应发生的重要因素。不同患者的年龄、性别、体质、疾病状况等都会对药物的反应产生影响。例如，老年人、儿童、孕妇等特殊人群的药物代谢和排泄能力较弱，可能更容易出现不良反应。Furthermore,individualdifferencesinpatientsarealsoanimportantfactoraffectingtheoccurrenceofadversereactionstotraditionalChinesemedicineinjections.Theage,gender,physicalcondition,anddiseasestatusofdifferentpatientscanallaffecttheresponsetomedication.Forexample,specialpopulationssuchastheelderly,children,andpregnantwomenhaveweakerdrugmetabolismandexcretionabilitiesandmaybemorepronetoadversereactions.用药方式也是影响中药注射剂不良反应发生的原因之一。如果用药剂量过大、速度过快、用药时间过长，或者与其他药物同时使用，都可能增加不良反应的风险。ThemedicationmethodisalsooneofthereasonsthataffectstheoccurrenceofadversereactionsintraditionalChinesemedicineinjections.Ifthedosageofmedicationistoohigh,thespeedistoofast,thedurationofmedicationistoolong,oritisusedtogetherwithotherdrugs,itmayincreasetheriskofadversereactions.中药注射剂不良反应及类过敏反应的发生原因涉及多个方面，需要从药物性质、生产工艺、患者个体差异、用药方式等多个角度进行深入研究和分析，以便更好地预防和控制不良反应的发生。ThecausesofadversereactionsandallergicreactionsintraditionalChinesemedicineinjectionsinvolvemultipleaspects,andrequirein-depthresearchandanalysisfrommultipleperspectivessuchasdrugproperties,productionprocesses,individualpatientdifferences,andmedicationmethods,inordertobetterpreventandcontroltheoccurrenceofadversereactions.五、中药注射剂不良反应及类过敏反应的预防与应对措施PreventionandresponsemeasuresforadversereactionsandallergicreactionsoftraditionalChinesemedicineinjections中药注射剂作为传统中药与现代医学技术相结合的产物，已经在临床治疗中发挥了重要作用。然而，其不良反应及类过敏反应的问题也不容忽视。因此，对于中药注射剂的预防与应对措施显得尤为关键。TraditionalChinesemedicineinjections,asaproductofthecombinationoftraditionalChinesemedicineandmodernmedicaltechnology,haveplayedanimportantroleinclinicaltreatment.However,theissuesofadversereactionsandallergicreactionscannotbeignored.Therefore,thepreventionandresponsemeasuresfortraditionalChinesemedicineinjectionsareparticularlycrucial.质量控制：应严格把控中药注射剂的原材料质量、生产工艺以及最终产品的质量。这包括对原材料的采集、储存、炮制，以及生产过程中的无菌操作、制剂的稳定性等进行严格监控。Qualitycontrol:Thequalityofrawmaterials,productionprocess,andfinalproductoftraditionalChinesemedicineinjectionsshouldbestrictlycontrolled.Thisincludesstrictmonitoringofthecollection,storage,andprocessingofrawmaterials,aswellasasepticoperationsduringproductionandthestabilityofformulations.临床试验：在中药注射剂上市前，应进行全面、科学、严谨的临床试验，以评估其有效性和安全性。同时，对于已上市的中药注射剂，也应定期进行再评价，以确保其安全性和有效性。Clinicaltrials:BeforethelaunchoftraditionalChinesemedicineinjections,comprehensive,scientific,andrigorousclinicaltrialsshouldbeconductedtoevaluatetheireffectivenessandsafety.Atthesametime,regularreevaluationsshouldalsobeconductedforChinesemedicineinjectionsthathavealreadybeenmarketedtoensuretheirsafetyandeffectiveness.合理使用：医务人员应充分了解中药注射剂的使用说明和注意事项，避免超剂量、超疗程使用，减少不必要的联合用药，以降低不良反应的发生风险。Reasonableuse:MedicalpersonnelshouldfullyunderstandtheinstructionsandprecautionsfortheuseoftraditionalChinesemedicineinjections,avoidexcessivedosageandtreatment,reduceunnecessarycombinationtherapy,andreducetheriskofadversereactions.不良反应监测：医疗机构应建立完善的中药注射剂不良反应监测体系，及时发现、报告和处理不良反应事件。同时，对于出现的不良反应，应进行详细记录和分析，为改进药品质量和临床用药提供参考。Adversereactionmonitoring:MedicalinstitutionsshouldestablishacomprehensivemonitoringsystemforadversereactionsoftraditionalChinesemedicineinjections,andpromptlydetect,report,andhandleadversereactionevents.Atthesametime,detailedrecordingandanalysisofadversereactionsshouldbeconductedtoprovidereferenceforimprovingdrugqualityandclinicaluse.过敏反应处理：对于出现类过敏反应的患者，应立即停药，并进行抗过敏治疗。对于严重的过敏反应，如过敏性休克，应立即进行抢救，确保患者生命安全。Allergicreactiontreatment:Forpatientswithsimilarallergicreactions,medicationshouldbestoppedimmediatelyandantiallergictreatmentshouldbecarriedout.Forsevereallergicreactions,suchasanaphylacticshock,immediaterescueshouldbecarriedouttoensurethepatient'slifesafety.教育培训：加强对医务人员的培训和教育，提高其对中药注射剂不良反应和类过敏反应的认识和处理能力。同时，也应向患者和公众普及中药注射剂的安全使用知识，提高其自我保护和风险意识。Educationandtraining:Strengthenthetrainingandeducationofmedicalpersonnel,improvetheirunderstandingandabilitytohandleadversereactionsandallergicreactionstotraditionalChinesemedicineinjections.Atthesametime,itisalsonecessarytopopularizetheknowledgeofsafeuseoftraditionalChinesemedicineinjectionstopatientsandthepublic,andimprovetheirself-protectionandriskawareness.中药注射剂的预防与应对措施需要从多个方面入手，包括质量控制、临床试验、合理使用、不良反应监测、过敏反应处理以及教育培训等。只有这样，才能确保中药注射剂的安全性和有效性，保障患者的用药安全。ThepreventionandresponsemeasuresfortraditionalChinesemedicineinjectionsneedtobeapproachedfrommultipleaspects,includingqualitycontrol,clinicaltrials,rationaluse,adversereactionmonitoring,allergicreactionmanagement,andeducationandtraining.OnlyinthiswaycanthesafetyandeffectivenessoftraditionalChinesemedicineinjectionsbeensured,andthemedicationsafetyofpatientsbeguaranteed.六、中药注射剂不良反应及类过敏反应的研究进展ResearchprogressonadversereactionsandallergicreactionsoftraditionalChinesemedicineinjections随着中药注射剂在临床的广泛应用，其不良反应及类过敏反应的问题也日益受到关注。近年来，针对中药注射剂的不良反应及类过敏反应的研究取得了显著的进展。WiththewidespreadapplicationoftraditionalChinesemedicineinjectionsinclinicalpractice,theissuesofadversereactionsandallergicreactionshavealsoreceivedincreasingattention.Inrecentyears,significantprogresshasbeenmadeinresearchontheadversereactionsandallergicreactionsoftraditionalChinesemedicineinjections.在不良反应方面，研究主要集中在对中药注射剂成分的安全性评估、药物相互作用、患者个体差异以及给药方式等因素的影响。通过对中药注射剂成分的深入研究，发现某些成分可能导致过敏反应、肝肾功能损害等不良反应。同时，药物相互作用也可能增加不良反应的风险。患者的年龄、性别、体质等个体差异也会对中药注射剂的反应产生影响。因此，在中药注射剂的临床应用中，应充分考虑这些因素，以减少不良反应的发生。Intermsofadversereactions,researchmainlyfocusesontheevaluationofthesafetyofcomponentsintraditionalChinesemedicineinjections,druginteractions,individualpatientdifferences,andtheimpactofadministrationmethods.Throughin-depthresearchonthecomponentsoftraditionalChinesemedicineinjections,ithasbeenfoundthatcertaincomponentsmaycauseadversereactionssuchasallergicreactionsanddamagetoliverandkidneyfunction.Meanwhile,druginteractionsmayalsoincreasetheriskofadversereactions.Individualdifferencessuchasage,gender,andphysicalconstitutionofpatientscanalsohaveanimpactontheresponseoftraditionalChinesemedicineinjections.Therefore,intheclinicalapplicationoftraditionalChinesemedicineinjections,thesefactorsshouldbefullyconsideredtoreducetheoccurrenceofadversereactions.在类过敏反应方面，研究发现中药注射剂引起的类过敏反应可能与药物中的杂质、添加剂或赋形剂等有关。这些成分可能引发机体的免疫应答，导致过敏反应的发生。中药注射剂的制备工艺、储存条件等也可能影响类过敏反应的发生。因此，改进中药注射剂的制备工艺、提高药物纯度、减少添加剂的使用等措施，有助于降低类过敏反应的风险。Intermsofallergicreactions,researchhasfoundthattheallergicreactionscausedbytraditionalChinesemedicineinjectionsmayberelatedtoimpurities,additives,orexcipientsinthedrug.Thesecomponentsmaytriggerthebody'simmuneresponse,leadingtotheoccurrenceofallergicreactions.ThepreparationprocessandstorageconditionsoftraditionalChinesemedicineinjectionsmayalsoaffecttheoccurrenceofallergicreactions.Therefore,improvingthepreparationprocessoftraditionalChinesemedicineinjections,increasingdrugpurity,andreducingtheuseofadditivescanhelpreducetheriskofallergicreactions.为了更好地了解中药注射剂的不良反应及类过敏反应的发生机制和预防措施，未来的研究需要进一步加强基础研究和临床试验的结合。通过深入研究中药注射剂的成分、作用机制以及药物与机体之间的相互作用关系，为临床安全用药提供科学依据。还需要加强对中药注射剂生产工艺和质量控制的研究，以提高药物的安全性和有效性。InordertobetterunderstandthemechanismsandpreventivemeasuresofadversereactionsandallergicreactionsintraditionalChinesemedicineinjections,futureresearchneedstofurtherstrengthenthecombinationofbasicresearchandclinicaltrials.Byconductingin-depthresearchonthecomponents,mechanismsofaction,andinteractionsbetweentraditionalChinesemedicineinjectionsandthebody,scientificbasisisprovidedforsafeclinicalmedication.ItisalsonecessarytostrengthenresearchontheproductionprocessandqualitycontroloftraditionalChinesemedicineinjectionstoimprovethesafetyandeffectivenessofdrugs.中药注射剂的不良反应及类过敏反应是当前中药研究领域的热点和难点问题。随着研究的深入和技术的进步，相信未来我们能够更好地解决这些问题，为中药注射剂的安全应用提供有力保障。TheadversereactionsandallergicreactionsoftraditionalChinesemedicineinjectionsarecurrentlyhotanddifficultissuesinthefieldoftraditionalChinesemedicineresearch.Withthedeepeningofresearchandtechnologicalprogress,webelievethatinthefuture,wecanbettersolvetheseproblemsandprovidestrongguaranteesforthesafeapplicationoftraditionalChinesemedicineinjections.七、结论Conclusion中药注射剂作为一种重要的药物制剂形式，在临床应用中发挥着重要作用。然而，其不良反应及类过敏反应的发生也引起了广泛关注。本文综述了近年来中药注射剂不良反应及类过敏反应的研究进展，旨在加深对这一问题的理解，并探讨未来的研究方向。TraditionalChinesemedicineinjections,asanimportantformofdrugformulation,playanimportantroleinclinicalapplications.However,theoccurrenceofitsadversereactionsandallergicreactionshasalsoattractedwidespreadattention.ThisarticlereviewstheresearchprogressonadversereactionsandallergicreactionsintraditionalChinesemedicineinjectionsinrecentyears,aimingtodeepenourunderstandingofthisissueandexplorefutureresearchdirections.通过对相关文献的梳理和分析，我们发现中药注射剂的不良反应及类过敏反应类型多样，临床表现复杂，涉及多个系统和器官。其中，过敏反应是最常见的不良反应类型，包括速发型和迟发型过敏反应。这些反应的发生与药物成分、个体差异、给药方式等多种因素有关。Throughthereviewandanalysisofrelevantliterature,wefoundthattherearevarioustypesofadversereactionsandallergicreactionsintraditionalChinesemedicineinjections,withcomplexclinicalmanifestationsinvolvingmultiplesystemsandorgans.Amongthem,allergicreactionsarethemostcommontypeofadversereactions,includingimmediateanddelayedallergicreactions.Theoccurrenceofthesereactionsisrelatedtovariousfactorssuch