Rabeprazole-sodium-Standard-LY307640-sodium-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemERabeprazolesodium(Standard)Cat.No.:HY-B0656ARCASNo.:117976-90-6Synonyms:LY307640sodium(Standard)分子式:C₁₈H₂₀N₃NaO₃S分子量:381.42作用靶点:ProtonPump;Apoptosis;Bacterial作用通路:MembraneTransporter/IonChannel;Apoptosis;Anti-infection储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:100mg/mL(262.18mM;Needultrasonic)H2O:66.67mg/mL(174.79mM;ultrasonicandadjustpHto11with1MNaOH)SolventMass1mg5mg10mgConcentration制备储备液1mM2.6218mL13.1089mL26.2178mL5mM0.5244mL2.6218mL5.2436mL10mM0.2622mL1.3109mL2.6218mLBIOLOGICALACTIVITY生物活性Rabeprazole(sodium)(Standard)是Rabeprazole(sodium)的分析标准品。本产品用于研究及分析应用。Rabeprazolesodium(LY307640sodium)是一种二代质子泵抑制剂(pumpinhibitor,PPI)，不可逆地抑制胃H+/K+-ATPase。Rabeprazolesodium诱导细胞凋亡(apoptosis)。Rabeprazolesodium也抑制尿苷核苷核糖水解酶(UNH)，IC50为0.3μM[1]。Rabeprazolesodium可用于胃溃疡和胃食管反流的研究[1][2][3]。IC50&TargetPumpinhibitor(PPI)[1]IC50:0.3μM(UNH)[1]H+/K+-ATPase[2]1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEApoptosis[2]REFERENCESTaraAShea,etal.IdentificationofProton-PumpInhibitorDrugsThatInhibitTrichomonasVaginalisUridineNucleosideRibohydrolase.BioorgMedChemLett.2014Feb15;24(4):1080-4.AlyAMShaalan,etal.SupplementWithCalciumorAlendronateSuppressesOsteopeniaDuetoLongTermRabeprazoleTreatmentinFemaleMice:InfluenceonBoneTRAPandOsteopontinLevels.FrontPharmacol.2020May13;11:583.MengliGu,etal.RabeprazoleExhibitsAntiproliferativeEffectsonHumanGastricCancerCellLines.OncolLett.2014Oct;8(4):1739-1744.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02